{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:05:03Z","timestamp":1792782303173,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T00:00:00Z","timestamp":1423699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Stiftung Institut f\u00fcr Herzinfarktforschung (IHF)","id":[{"id":"https:\/\/ror.org\/0213d4b59","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005971","name":"Deutsche Herzstiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005971","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Abbott Vascular, Germany"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To analyze risk and outcomes of complications during and after MitraClip implantation using multicenter data from the prospective German Transcatheter Mitral Valve Interventions (TRAMI) registry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and Results<\/jats:title>\n                    <jats:p>Data of 828 patients (mean age: 76.0 [71\u201381] years, 327 (40%) females) undergoing MitraClip implantation in Germany between 2010 and 2013 were analyzed. Most patients (85%) underwent elective procedures with on average implantation of 1.4\u2009\u00b1\u20090.6 clips. Emergent cardiac surgery was not required; a single patient died intraoperatively. During the in\u2010hospital period, complications occurred in 215 (25.9%) patients, of which 106 (12.8%) were considered major. Major bleeding complications were among the most frequent major complications (7.4%), while rates of pericardial tamponade (1.9%) and clip\u2010specific complications (embolization: 0%, partial clip detachment: 1.9%) were low. In\u2010hospital death, stroke or myocardial infarction (MACCE) occurred in 2.2, 0.9, and 0% patients, respectively. Patients with complications appeared to be older and more critically ill pre\u2010interventionally; in\u2010hospital mortality was significantly higher as compared to those without procedural complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>MitraClip implantation appears to be a safe treatment option with low rates of MACCE and clip\u2010specific complications. Nevertheless, MitraClip therapy is not without complications. Careful patient selection and improvements in preventing peri\u2010procedural bleeding have the potential of reducing post\u2010procedural complications and improving outcomes. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.25838","type":"journal-article","created":{"date-parts":[[2015,1,19]],"date-time":"2015-01-19T10:43:22Z","timestamp":1421664202000},"page":"728-735","source":"Crossref","is-referenced-by-count":90,"title":["Risk and outcomes of complications during and after MitraClip implantation: Experience in 828 patients from the German TRAnscatheter mitral valve interventions (TRAMI) registry"],"prefix":"10.1002","volume":"86","author":[{"given":"Holger","family":"Eggebrecht","sequence":"first","affiliation":[{"name":"Cardioangiological Center Bethanien Frankfurt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sibylle","family":"Schelle","sequence":"additional","affiliation":[{"name":"Cardioangiological Center Bethanien Frankfurt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Puls","sequence":"additional","affiliation":[{"name":"Department of Cardiology University Medical Centre G\u00f6ttingen G\u00f6ttingen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Plicht","sequence":"additional","affiliation":[{"name":"Department of Cardiology West\u2010German Heart and Vascular Center, University Hospital Essen, University of Duisburg\u2010Essen Essen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph Stephan","family":"von Bardeleben","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology University Medical Center Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Butter","sequence":"additional","affiliation":[{"name":"Heart Centre Brandenburg Bernau\/Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas E.","family":"May","sequence":"additional","affiliation":[{"name":"Department of Cardiology Eberhard\u2010Karls\u2010University Tuebingen Tuebingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Lubos","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology University Heart Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Boekstegers","sequence":"additional","affiliation":[{"name":"Department for Cardiology and Angiology Helios Heart Center Siegburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taoufik","family":"Ouarrak","sequence":"additional","affiliation":[{"name":"Institute of Myocardial Infarction Research Ludwigshafen 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