{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T08:16:37Z","timestamp":1695716197391},"reference-count":16,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T00:00:00Z","timestamp":1424304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"JW Medical System"},{"name":"National Key Technology R&D Program in the 12th Five-Year Plan of China","award":["2011BAI11B07, Beijing, China"],"award-info":[{"award-number":["2011BAI11B07, Beijing, China"]}]},{"name":"Key Project of the National 12th Five-Year Research Program of China","award":["2012ZX093016-002, Beijing, China"],"award-info":[{"award-number":["2012ZX093016-002, Beijing, China"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the preliminary safety and efficacy of the EXCEL II stent system.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Although the first biodegradable polymer drug\u2010eluting stent (BP\u2010DES), EXCEL, was launched nearly a decade ago, in\u2010stent restenosis and stent thrombosis remain pertinent clinical problems in practice. A new cobalt\u2010chromium BP\u2010DES EXCEL II has been developed with the aim of improving stent safety and efficacy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five patients with single de novo native coronary lesions were enrolled and randomized to two groups in a 2:1 ratio, the 4\u2010month follow\u2010up group (<jats:italic>n<\/jats:italic>\u2009=\u200930) and the 12\u2010month follow\u2010up group (<jats:italic>n<\/jats:italic>\u2009=\u200915). All patients underwent percutaneous coronary intervention (PCI) with the EXCEL II stent system. Quantitative coronary angiography (QCA) and optical coherence tomography (OCT) were used to assess coronary vasculature at the designated 4\u2010 or 12\u2010month follow\u2010up. The primary outcome was major adverse cardiac events (MACE) at 30 days post\u2010PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No MACE, thrombotic events, or target lesion failure was found in the 45 patients during the 12\u2010month follow\u2010up. There was no significant difference (<jats:italic>P<\/jats:italic>\u2009&gt;\u20090.05) between the two groups in terms of in\u2010stent and in\u2010segment late lumen loss (LLL). No in\u2010stent and in\u2010segment restenosis was found in either group. At follow\u2010up, the ratio of &gt;10% uncovered struts per lesion was 26.67% in the 4\u2010month group and 0% in the 12\u2010month group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05). Neointimal coverage in the 12\u2010month group was significantly better than in the 4\u2010month group (98.58% vs. 93.51%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This first\u2010in\u2010man study demonstrates promising feasibility, safety, and efficacy of EXCEL II stents. These stents were found to have rapid endothelialization and low LLL rates at 4 and 12 months after implantation. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25862","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T05:48:31Z","timestamp":1422510511000},"page":"744-751","source":"Crossref","is-referenced-by-count":8,"title":["First\u2010in\u2010man study evaluating the safety and efficacy of a second generation biodegradable polymer sirolimus\u2010eluting stent in the treatment of patients with de novo coronary lesions: Clinical, Angiographic, and <scp>OCT<\/scp> outcomes of <scp>CREDIT<\/scp>\u20101"],"prefix":"10.1002","volume":"85","author":[{"given":"Geng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhongwei","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fuwai Hospital, Chinese Academy of Medical Sciences &amp; Peking Union Medical College Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quanmin","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozeng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingyan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiwei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaoyi","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology General Hospital of Shenyang Military Region Shenyang Liaoning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fuwai Hospital, Chinese Academy of Medical Sciences &amp; 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