{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:53:19Z","timestamp":1787939599998,"version":"build-2784847793"},"reference-count":22,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2015,2,19]],"date-time":"2015-02-19T00:00:00Z","timestamp":1424304000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"VENUS NedTech, Hangzhou, China","award":["80,000 USD"],"award-info":[{"award-number":["80,000 USD"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to describe the morphological characteristics of aortic valve disease in a Chinese population presenting for transcatheter aortic valve replacement (TAVR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Racial and regional differences are known to exist in aortic stenosis (AS), but limited data exist comparing the specific anatomical variations between populations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were prospectively evaluated in a Chinese population presenting for TAVR in the Venus A\u2010Valve trial, the first trial evaluating TAVR in China. A systematic anatomical assessment protocol employed contrast\u2010enhanced computed tomography (CT) in all the cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 120 consecutive patients were studied. Of these, 61 (50.7%) were patients with tricuspid, 57 (47.5%) bicuspid, and 2 (1.7%) unicuspid valve morphologies. Of the 57 cases with bicuspid valve, 31 (54.4%) had no raphe (Sievers classification, type 0) and 26 (45.6%) were of raphe type. Although the incidence of bicuspid valve morphology was more than a third in the northern Chinese population, this was lower than the eastern Chinese population (<jats:italic>P<\/jats:italic>\u2009=\u20090.035), in whom the incidence was more than half. A comparison of tricuspid morphologies in China versus a Western series of 229 consecutive patients undergoing TAVR assessed with CT showed a threefold excess of leaflet calcium burden in China, with a leaflet calcium volume of 421 mm<jats:sup>3<\/jats:sup> (IQR, 188\u2013688 mm<jats:sup>3<\/jats:sup>) versus 142 mm<jats:sup>3<\/jats:sup> (IQR, 58\u2013267 mm<jats:sup>3<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Patients presenting for TAVR in China have a very high frequency of bicuspid valve morphology. Even in tricuspid disease, there are clear differences to Western patients, with a high calcium burden, which presents challenges for TAVR in this population (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/ClinicalTrials.gov\">ClinicalTrials.gov<\/jats:ext-link> NCT01683474). \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25863","type":"journal-article","created":{"date-parts":[[2015,1,29]],"date-time":"2015-01-29T05:56:19Z","timestamp":1422510979000},"page":"752-761","source":"Crossref","is-referenced-by-count":71,"title":["Morphological characteristics of severe aortic stenosis in China: Imaging corelab observations from the first Chinese transcatheter aortic valve trial"],"prefix":"10.1002","volume":"85","author":[{"given":"Hasan","family":"Jilaihawi","sequence":"first","affiliation":[{"name":"Division of Cardiology Cedars\u2010Sinai Heart Institute Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjian","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuejin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Xu","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory Fuwai Hospital, National Center for Cardiovascular Diseases Beijing 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Radiology Fuwai Hospital, National Center for Cardiovascular Diseases Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery Fuwai Hospital, National Center for Cardiovascular Disease Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj R.","family":"Makkar","sequence":"additional","affiliation":[{"name":"Division of Cardiology Cedars\u2010Sinai Heart Institute Los Angeles California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Horst","family":"Sievert","sequence":"additional","affiliation":[{"name":"Department of Cardiology CardioVascular Center Frankfurt Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runlin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Cardiology Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing 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