{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:28:56Z","timestamp":1789950536838,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,2,25]],"date-time":"2015-02-25T00:00:00Z","timestamp":1424822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Boston Scientific Corporation, Marlborough, MA, USA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,11,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The TAXUS Element (ION) platinum chromium paclitaxel\u2010eluting stent (PtCr\u2010PES) incorporates a thin (81 \u03bcm) strut design with a similar polymer and drug dose density as prior PES. The pivotal PERSEUS trial program consisted of two studies: PERSEUS Workhorse (WH) and PERSEUS Small Vessel (SV). The PERSEUS WH trial demonstrated the PtCr\u2010PES to be non\u2010inferior to the predicate TAXUS Express PES (TE\u2010PES) for target lesion failure (TLF) at 1 year and in\u2010segment angiographic percent diameter stenosis at 9 months. The PERSEUS SV trial demonstrated the PtCr\u2010PES to be superior to a historical bare metal stent (BMS) for angiographic late lumen loss at 9 months. Long\u2010term (5\u2010year) clinical outcomes following PtCr\u2010PES have not been previously reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PERSEUS WH was a prospective, Bayesian, 3:1 randomized (PtCr\u2010PES vs. TE\u2010PES) trial in patients with lesion length \u226428 mm and vessel diameter \u22652.75 to \u22644.0 mm. PERSEUS SV was a prospective, single\u2010arm trial in patients with lesion length \u226420 mm and vessel diameter \u22652.25 to &lt;2.75 mm comparing PtCr\u2010PES to a matched historical BMS control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among randomized subjects in the PERSEUS WH study, clinical event rates at 5 years were similar between treatment groups, including TLF (12.9% TE\u2010PES vs. 12.1% PtCr\u2010PES; <jats:italic>P<\/jats:italic>\u2009=\u20090.66). In the PERSEUS SV study, 5\u2010year rates of MACE, and TLF were significantly lower for PtCr\u2010PES (vs. BMS) following adjustment for baseline characteristics and were primarily due to lower target lesion revascularization rates (27.2% BMS vs. 14.9% PtCr\u2010PES; <jats:italic>P<\/jats:italic>\u2009=\u20090.049).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>At 5 years, the PtCr\u2010PES provides efficacy and safety that is comparable to the TE\u2010PES and superior efficacy with similar safety when compared with BMS in smaller caliber vessels. Cumulative stent thrombosis rates remained low and similar through 5 years for both DES platforms. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25877","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T17:47:57Z","timestamp":1423763277000},"page":"994-1001","source":"Crossref","is-referenced-by-count":6,"title":["Long\u2010term follow\u2010up of the platinum chromium TAXUS element (ION) stent"],"prefix":"10.1002","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1086-127X","authenticated-orcid":false,"given":"Dean J.","family":"Kereiakes","sequence":"first","affiliation":[{"name":"The Christ Hospital Heart and Vascular Center\/the Lindner Center for Research and Education at the Christ Hospital Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louis A.","family":"Cannon","sequence":"additional","affiliation":[{"name":"The Cardiac &amp; Vascular Research Center McLaren Northern Michigan Hospital Cardiac and Vascular Research Center of Northern Michigan Petoskey Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira","family":"Dauber","sequence":"additional","affiliation":[{"name":"Department of Cardiology Swedish\u2010HealthOne Medical Center Englewood Colorado"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Ball","sequence":"additional","affiliation":[{"name":"The Heart Center Institution St. Vincent's Hospital Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry","family":"Bertolet","sequence":"additional","affiliation":[{"name":"Director Cardiac Catheterization Laboratory North Mississippi Medical Center Tupelo Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Foster","sequence":"additional","affiliation":[{"name":"Cardiovascular Services Sisters of Charity Providence Hospital  Columbia South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey Y.","family":"Nersesov","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Boston Scientific Corporation Marlborough Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul L.","family":"Underwood","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Boston Scientific Corporation Marlborough Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic J.","family":"Allocco","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Boston Scientific Corporation Marlborough Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith D.","family":"Dawkins","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Boston Scientific Corporation Marlborough Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.15420\/icr.2011.6.2.134"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.04.011"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV6I8A161"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-11-1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.10.1215"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.01.010"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.903"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.01.007"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV6I5A105"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.12.131"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9290(02)00446-3"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/14017430902785493"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)00570-2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1409312"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCA.0b013e32835b3932"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.25877","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.25877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:56:50Z","timestamp":1696615010000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.25877"}},"subtitle":["The PERSEUS Workhorse and Small Vessel Trial Five\u2010Year Results"],"short-title":[],"issued":{"date-parts":[[2015,2,25]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2015,11,15]]}},"alternative-id":["10.1002\/ccd.25877"],"URL":"https:\/\/doi.org\/10.1002\/ccd.25877","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,2,25]]}}}