{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:37:50Z","timestamp":1788871070009,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,3,25]],"date-time":"2015-03-25T00:00:00Z","timestamp":1427241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Medicines Company, Parsippany, NJ"},{"name":"Cohen, are consultants to The Medicines Company"},{"name":"Fan are employees and shareholders of The Medicines Company"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We sought to estimate the direct costs (in\u2010hospital and 30\u2010day) associated with an intraprocedural thrombotic event (IPTE) among patients with non\u2010ST\u2010segment elevation acute coronary syndromes (NSTEACS) undergoing percutaneous coronary intervention (PCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Patients with IPTE have higher rates of in\u2010hospital and 30\u2010day major adverse cardiac events than patients without IPTE. The extent to which IPTE also add to medical costs is unknown.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Hospital costs for patients in the ACUITY Trial were compared between patients with and without IPTE. Adjusted comparisons were performed using generalized linear models (GLMs). All costs are reported in 2012 US dollars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 1,307 patients with both core laboratory\u2010based angiographic assessment and detailed economic data were included in the final study population. IPTE occurred in 52 patients (4.0%). Median in\u2010hospital costs were higher in patients with IPTE than in those without IPTE ($23,719 vs. $18,419,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.01). Thirty\u2010day median costs were also higher for IPTE patients ($23,719 vs. $19,556,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.05). After adjusting for baseline differences, IPTE was associated with 19.5% (95% CI: [2.8\u201338.8%],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.02) and 18.9% (95% CI: [1.2\u201339.7%],\n                      <jats:italic>P<\/jats:italic>\n                      \u2009=\u20090.04) increases in in\u2010hospital and 30\u2010day costs, respectively. These relative differences represent median increases of $3,592 in initial hospital costs and $3,696 in 30\u2010day costs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The occurrence of IPTE during the index PCI in patients with NSTEACS is associated with substantial increases in\u2010hospital and 30\u2010day costs. These findings suggest that strategies to prevent IPTE may be associated with important cost offsets as well as improved clinical outcomes. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/ccd.25909","type":"journal-article","created":{"date-parts":[[2015,2,28]],"date-time":"2015-02-28T00:29:38Z","timestamp":1425083378000},"page":"30-39","source":"Crossref","is-referenced-by-count":4,"title":["Cost implications of intraprocedural thrombotic events during\n                    <scp>PCI<\/scp>"],"prefix":"10.1002","volume":"86","author":[{"given":"Stephanie","family":"Plent","sequence":"first","affiliation":[{"name":"The Medicines Company Parsippany New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Fan","sequence":"additional","affiliation":[{"name":"The Medicines Company Parsippany New 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York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duane S.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center and Harvard Medical School Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"McEntegart","sequence":"additional","affiliation":[{"name":"Department of Medicine Golden Jubilee National Hospital Glasgow Scotland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Saint\u2010Luke's Mid America Heart Institute and University of Missouri\u2010Kansas City School of Medicine Kansas City Missouri"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregg W.","family":"Stone","sequence":"additional","affiliation":[{"name":"Columbia University Medical Center, New York Presbyterian Hospital and the Cardiovascular Research Foundation New York New 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