{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:09:56Z","timestamp":1762506596538},"reference-count":23,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T00:00:00Z","timestamp":1439424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Objectives\/Background<\/jats:title><jats:p>To compare the 1\u2010year clinical outcomes after implantation of the amphilimus, polymer\u2010free stent (Cre8) versus new generation everolimus\u2010eluting stents (EESs) in a real\u2010world patient registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 187 consecutive patients treated with Cre8 between January 2011 and August 2013 in four Italian centers were included. These were propensity matched with 150 patients treated with new generation EES during the same period. Primary outcome was 1\u2010year major adverse cardiovascular events (MACE), defined as all\u2010cause death, myocardial infarction, and target vessel revascularization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both groups had similar baseline characteristics, including diabetes (28% Cre8 vs. 27.3% EES, <jats:italic>P<\/jats:italic>\u2009=\u20090.972) and previous percutaneous coronary intervention (56% Cre8 vs. 58% EES, <jats:italic>P<\/jats:italic>\u2009=\u20090.726). There was a higher prevalence of B2\/C lesions in the EES group (70.1% vs. 83.8%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Total stent length per patient was similar. There were no significant differences in 1\u2010year estimated MACE (7.4% Cre8 vs. 10.2% EES, <jats:italic>P<\/jats:italic>\u2009=\u20090.261), all\u2010cause mortality (1.3% Cre8 vs. 1.4% EES, <jats:italic>P<\/jats:italic>\u2009=\u20090.823), target vessel revascularization (5.2% Cre8 vs. 8.8% EES, <jats:italic>P<\/jats:italic>\u2009=\u20090.169), and target lesion revascularization (3% Cre8 vs. 7.4% EES, <jats:italic>P<\/jats:italic>\u2009=\u20090.108) between the two groups. When adjusting for differences in baseline lesion characteristics, hazard ratio<jats:sub>Cre8\/EES<\/jats:sub> for MACE was not significantly different between the two groups (0.75, 95% confidence interval 0.37\u20131.53, <jats:italic>P<\/jats:italic><jats:sub>noninferiority<\/jats:sub>\u2009=\u20090.001, <jats:italic>P<\/jats:italic><jats:sub>superiority<\/jats:sub>\u2009=\u20090.432). In patients with diabetes (Cre8, <jats:italic>n<\/jats:italic>\u2009=\u200942; EEE, <jats:italic>n<\/jats:italic>\u2009=\u200941), 1\u2010year target lesion revascularization was 2.5% in the Cre8 group versus 14.6% in the EES group (<jats:italic>P<\/jats:italic>\u2009=\u20090.056).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a \u201creal\u2010world\u201d patient registry, the Cre8 stent is associated with noninferior 1\u2010year MACE rates compared with that of new generation EES. Trends of superior efficacy in patients with diabetes treated with Cre8 require further investigation. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25931","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T05:41:50Z","timestamp":1439444510000},"page":"1168-1176","source":"Crossref","is-referenced-by-count":9,"title":["Clinical outcomes of real\u2010world patients treated with an amphilimus polymer\u2010free stent versus new generation everolimus\u2010eluting stents"],"prefix":"10.1002","volume":"86","author":[{"given":"Vasileios F.","family":"Panoulas","sequence":"first","affiliation":[{"name":"Cardiovascular science division, Faculty of Medicine, National Heart and Lung Institute Imperial College London London Greater London United Kingdom"},{"name":"Interventional Cardiology Department, EMO GVM Centro Cuore Columbus Milan Italy"},{"name":"Interventional Cardiology Department San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azeem","family":"Latib","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department, EMO GVM Centro Cuore Columbus Milan Italy"},{"name":"Interventional Cardiology Department San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charbel","family":"Naim","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsumasa","family":"Sato","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Ielasi","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department, Azienda Ospedaliera Bolognini Seriate Bergamo Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurizio","family":"Tespili","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department, Istituto Clinico San Ambrogio Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cosmo","family":"Godino","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luca","family":"Testa","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department, Istituto Clinico San Ambrogio Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Bedogni","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department, Istituto Clinico San Ambrogio Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Colombo","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department, EMO GVM Centro Cuore Columbus Milan Italy"},{"name":"Interventional Cardiology Department San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,8,13]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032441"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012843"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)17275-9"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.061"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f6530"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.107.144220"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1586\/17434440.6.1.33"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.01.008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25272"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.10.236"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV5I7A146"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.08.001"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.007"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I9A173"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.12.009"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/157340308783565429"},{"key":"e_1_2_6_20_1","unstructured":"RomagueraR. cre8 in diabetic patients. 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