{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T21:55:33Z","timestamp":1764194133308},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T00:00:00Z","timestamp":1430870400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,11,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Few data are available about whether aortic root calcification may impact the outcomes after transcatheter aortic valve implantation (TAVI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study sought to evaluate the impact of aortic root calcification volume on clinical outcome after TAVI with balloon expandable Edwards Sapien XT valve (Edwards Lifesciences, Irvine, California).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 162 TAVI patients (aged 84.0 [Interquartile Range (IQR) 81.0\u201384.0] years, Logistic EuroSCORE 14.5 [IQR 9.8\u201325.1]) with preprocedural MDCT were studied. Aortic root calcification volume was measured by MDCT image and using the dedicated software for aortic valve assessment (the automated 3mensio<jats:sup>TM<\/jats:sup> Valves 5.1, sp1, 3mensio Pie Medical Imaging BV, Maastricht, the Netherlands). A valve calcification index (VCI) was defined as calcification volume (mm<jats:sup>3<\/jats:sup>)\/body surface area (mm<jats:sup>2<\/jats:sup>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>VCI was significantly higher among patients with 30\u2010day mortality. A VCI threshold of 517.4 (area under the curve 0.69, 95% CI 0.50\u20130.87, <jats:italic>P<\/jats:italic>\u2009=\u20090.03) predicted a higher incidence of annulus rupture (9.1 vs. 0.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.02) and cardiac tamponade (12.7 vs. 1.9%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01), lower device success (83.6% vs. 95.3%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01) and 30\u2010day survival rate (80.0% vs. 97.2%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Multivariate logistic regression analysis showed only ejection fraction and VCI were identified as independent predictors of 30\u2010day mortality (Odds ratio 0.948 [95% confidence interval 0.909\u20130.988], <jats:italic>P<\/jats:italic>\u2009=\u20090.012, Odds ratio 1.003 [95% confidence interval 1.001\u20131.005], <jats:italic>P<\/jats:italic>\u2009=\u20090.013, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Significantly worse acute clinical outcomes after Edwards valve implantation were observed in patients with large amount of aortic annulus calcifications quantitatively measured by dedicated MDCT software. Application of VCI may prove helpful in prediction of clinical outcomes after TAVI. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25986","type":"journal-article","created":{"date-parts":[[2015,5,6]],"date-time":"2015-05-06T16:30:26Z","timestamp":1430929826000},"page":"1105-1113","source":"Crossref","is-referenced-by-count":11,"title":["Prognostic value of aortic root calcification volume on clinical outcomes after transcatheter balloon\u2010expandable aortic valve implantation"],"prefix":"10.1002","volume":"86","author":[{"given":"Yusuke","family":"Watanabe","sequence":"first","affiliation":[{"name":"Division of Cardiology Department of Internal Medicine Teikyo University School of Medicine Tokyo Japan"},{"name":"Department of Cardiology and Cardiovascular Surgery Institut Cardiovasculaire Paris Sud Orsay 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