{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:53:57Z","timestamp":1767995637812,"version":"3.49.0"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Science and Higher Education","award":["N402 526839"],"award-info":[{"award-number":["N402 526839"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,2,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter paravalvular leak closure (TPVLC) offers a viable alternative to reoperation but optimal technical strategy is still to be defined. We present a prospective TPVLC registry in which safety and efficacy of multi\u2010plug, single\u2010stage approach were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with heart failure (HF) symptoms caused by PVL were qualified for TPVLC by Heart Team. Ante\u2010 or retrograde access was employed for mitral while retrograde only for aortic PVLs. Two to 4 AVP 3 devices were simultaneously implanted into each PVL. Endpoints were defined according to VARC\u20102.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 64 referred patients 49, with either mechanical valves (<jats:italic>n<\/jats:italic>\u2009=\u200930) or stented bioprostheses, were eligible for TPVLC. PVL location was mitral (<jats:italic>n<\/jats:italic>\u2009=\u200929) or aortic (<jats:italic>n<\/jats:italic>\u2009=\u200920). In aortic group acute procedural success (APS) ratio was 100% and no MACCEs occurred. In mitral group, first\u2010attempt TPVLC was successful in 22 cases (4\/4 in transapical and 18\/25 in transseptal access). Second\u2010attempt transapical procedure followed transseptal failure in 5 patients. Mitral TPVLC ultimately proved efficient in 89.7% with 76.5% APS. Cumulatively, TPVLC was accomplished in 46 subjects (93.9%) with 78% APS. When successful, it led to a significant decrease of NT\u2010proBNP concentration and HF symptoms regression. Periprocedural safety endpoints were met in three patients and included non\u2010disabling stroke, and two access site\u2010related complications. In device failure group two patients died (end\u2010stage HF) and two others were rehospitalized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>TPVLC with simultaneous deployment of multiple AVP III occluders is feasible with high device success rate and no significant periprocedural complications. The clinical benefits of reduction of HF symptoms and hemolysis are evident after 30 days and persist up to 1 year without recurrence of PVL. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25992","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T11:09:27Z","timestamp":1431342567000},"page":"478-487","source":"Crossref","is-referenced-by-count":28,"title":["Multiplug paravalvular leak closure using Amplatzer Vascular Plugs III: A prospective registry"],"prefix":"10.1002","volume":"87","author":[{"given":"Grzegorz","family":"Smolka","sequence":"first","affiliation":[{"name":"3rd Division of Cardiology Medical University of Silesia Katowice Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piotr","family":"Pysz","sequence":"additional","affiliation":[{"name":"Division of Cardiology Medical University of Silesia Katowice 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