{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T15:23:13Z","timestamp":1761578593156},"reference-count":42,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T00:00:00Z","timestamp":1431302400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Clinical trials have shown a short\u2010term benefit of drug\u2010eluting stents (DES) compared to vascular brachytherapy (VBT) for treatment of in\u2010stent restenosis (ISR). The long\u2010term benefits of DES vs. VBT are conflicting in the literature. This study aimed to do a meta\u2010analysis of long\u2010term outcomes of DES compared to VBT for treatment of ISR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, EMBASE, Cochrane Central and unpublished data were searched for cohort studies and randomized controlled trials (RCTs) that directly compared VBT to DES for the treatment of ISR. We evaluated the following outcomes at 2\u20135 years of follow\u2010up: target lesion revascularization (TLR), target vessel revascularization (TVR), myocardial infarction (MI), stent thrombosis, cardiovascular (CV) mortality, and overall mortality. Heterogeneity was defined as <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup> values\u2009&gt;\u200925%. Review Manager 5.1 was used for statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 1,375 patients from five studies, of which three were RCTs. VBT was used to treat ISR in 685 (49.8%) patients. After a 2\u20135 year follow\u2010up, no significant differences were found between treatment groups regarding MI (<jats:italic>P<\/jats:italic>\u2009=\u20090.49), stent thrombosis (<jats:italic>P<\/jats:italic>\u2009=\u20090.86), CV mortality (<jats:italic>P<\/jats:italic>\u2009=\u20090.35), and overall mortality (<jats:italic>P<\/jats:italic>\u2009=\u20090.71). TLR (OR 2.37; CI 1.55\u20133.63; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and TVR (OR 2.23; CI 1.01\u20134.94; <jats:italic>P<\/jats:italic>\u2009=\u20090.05) were significantly increased in patients who received VBT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that DES are associated with decreased long\u2010term revascularization procedures when compared to VBT for the treatment of ISR. This benefit does not appear to be associated with a significant reduction in mortality or myocardial infarction. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.25998","type":"journal-article","created":{"date-parts":[[2015,5,11]],"date-time":"2015-05-11T11:12:48Z","timestamp":1431342768000},"page":"200-208","source":"Crossref","is-referenced-by-count":4,"title":["Vascular brachytherapy versus drug\u2010eluting stents in the treatment of in\u2010stent restenosis: A meta\u2010analysis of long\u2010term outcomes"],"prefix":"10.1002","volume":"87","author":[{"given":"Alexandre","family":"Benjo","sequence":"first","affiliation":[{"name":"Department of Cardiology Ochsner Medical Center New Orleans Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rhanderson N.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Miami Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tyrone","family":"Collins","sequence":"additional","affiliation":[{"name":"Department of Cardiology Ochsner Medical Center New Orleans Louisiana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Garcia","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Miami Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Y.","family":"Macedo","sequence":"additional","affiliation":[{"name":"Department of Cardiology Baylor College of Medicine Houston Texas"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georges","family":"El\u2010Hayek","sequence":"additional","affiliation":[{"name":"Department of Medicine St. Luke's Roosevelt Hospital Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Girish","family":"Nadkarni","sequence":"additional","affiliation":[{"name":"Department of Nephrology Ichan Mount Sinai School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emad","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Medicine St. Luke's Roosevelt Hospital Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. 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