{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T13:50:41Z","timestamp":1762955441218},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T00:00:00Z","timestamp":1432684800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Cordis Corporation (to e-SELECT Registry)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Diabetes mellitus has worse outcome after percutaneous coronary intervention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>We assessed stent thrombosis (ST), major adverse cardiac events (MACE), and major bleeding rates at 1 year after implantation of sirolimus\u2010eluting stents (SES) in patients with diabetes mellitus in a large multicenter registry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From May 2006 to April 2008, 15,147 unselected consecutive patients were enrolled at 320 centers in 56 countries in a prospective, observational registry after implantation of\u2009\u2265\u20091 SES. Source data were verified in 20% randomly chosen patients at\u2009&gt;\u2009100 sites. Adverse events were adjudicated by an independent Clinical Event Committee.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Complete follow\u2010up at 1 year was obtained in 13,693 (92%) patients, 4,577 (30%) of whom were diabetics. Within diabetics, 1,238 (9%) were insulin\u2010treated diabetics (ITD). Diabetics were older (64 vs. 62 years, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), with higher incidence of major coronary risk factors, co\u2010morbidities, and triple\u2010vessel coronary artery disease. Coronary lesions had smaller reference vessel diameter (2.88\u2009\u00b1\u20090.46 vs. 2.93\u2009\u00b1\u20090.45 mm, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and were more often heavily calcified (26.1% vs. 22.6%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). At 1 year, diabetics had higher MACE rate (6.8% vs. 3.9%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) driven by ITD (10.6% vs. 5.5%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Finally, diabetics had significant increase in ST (1.7% vs. 0.7%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), principally owing to ITD (3.4% vs. 1.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). There was an overall low risk of major bleeding during follow\u2010up, without significant difference among subgroups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In the e\u2010SELECT registry, diabetics represented 30% of patients undergoing SES implantation and had significantly more co\u2010morbidities and complex coronary lesions. Although 1\u2010year follow\u2010up documented good overall outcome in diabetics, higher ST and MACE rates were observed, mainly driven by ITD. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26026","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T16:45:54Z","timestamp":1432745154000},"page":"52-62","source":"Crossref","is-referenced-by-count":3,"title":["One\u2010year clinical outcomes after sirolimus\u2010eluting coronary stent implantation in diabetics enrolled in the worldwide e\u2010<scp>SELECT<\/scp> registry"],"prefix":"10.1002","volume":"87","author":[{"given":"Antonio L.","family":"Bartorelli","sequence":"first","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriele","family":"Egidy Assenza","sequence":"additional","affiliation":[{"name":"Centro Cardiologico Monzino, IRCCS University of Milan Milan 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