{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T07:43:51Z","timestamp":1696664631153},"reference-count":26,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T00:00:00Z","timestamp":1432857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Renal denervation (RDN) is a promising treatment option in addition to medical antihypertensive treatment in patients suffering from resistant hypertension. Despite the growing interest in RDN, the negative result of the Symplicity HTN\u20103 trial led to a debate on the efficacy of RDN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We systematically investigated the effects of RDN, evaluated by 24\u2010hr ambulatory blood pressure measurements (ABPM), in a consecutive series of patients with resistant hypertension, which was defined by a mean office systolic blood pressure (SBP) &gt;160 mm Hg (&gt;150 mm Hg in patients with diabetes). Patients with a mean 24\u2010hr SBP of less than 130 mm Hg at baseline were classified as pseudo\u2010resistant, while all other patients were classified as true\u2010resistant. After six months, we analyzed the response rates in true\u2010resistant and in pseudo\u2010resistant patients, respectively, by the means of 24\u2010hr ABPM. Thereby, patients with a reduction of more than 5 mm Hg in 24\u2010hr SBP were classified as responders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>RDN was performed in 106 patients. By 24\u2010hr ABPM, 20 patients (18.9%) were classified as pseudo\u2010resistant patients. In this cohort, we only found two responders (response rate 10%) six months after RDN. By contrast, in true\u2010resistant patients, the response rate was almost 60% and the mean BP reduction was \u221218.6\/\u22129 mm Hg in 24\u2010hr ABPM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We found a significant BP reduction in almost 60% of patients with true\u2010resistant hypertension, but only in 10% in patients with pseudo\u2010resistant hypertension. According to our results, patient selection seems to be crucial for acceptable response rates after RDN. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26030","type":"journal-article","created":{"date-parts":[[2015,5,29]],"date-time":"2015-05-29T19:39:41Z","timestamp":1432928381000},"source":"Crossref","is-referenced-by-count":0,"title":["Influence of pseudo\u2010resistance on the effect of renal denervation on 24\u2010hour ambulatory blood pressure levels"],"prefix":"10.1002","volume":"86","author":[{"given":"Thomas","family":"Lambert","sequence":"first","affiliation":[{"name":"1st Medical Department\u2014Cardiology Linz General Hospital, Johannes Kepler University School of Medicine Linz Linz Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Nahler","sequence":"additional","affiliation":[{"name":"1st Medical Department\u2014Cardiology Linz General Hospital, Johannes Kepler University School of Medicine Linz 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