{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T16:30:21Z","timestamp":1790613021317,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We attempted to characterize the anatomy, function, clinical consequences, and treatment of right\u2010sided anomalous coronary artery origin from the opposite side (R\u2010ACAOS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Anomalous aortic origin of a coronary artery is a source of great uncertainty in cardiology. A recent study by our group found that ACAOS had a high prevalence (0.48%) in a general population of adolescents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010seven consecutive patients were diagnosed with R\u2010ACAOS according to a new definition: ectopic right coronary artery (RCA) with an intramural proximal course. We used intravascular ultrasonograms of the RCA to quantify congenital stenosis (in patients with potentially serious clinical presentations), and we correlated these measurements with clinical manifestations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All patients had some proximal intramural stenosis (mean 50%, range 16\u201383% of the cross\u2010sectional area). Forty\u2010two patients (62%) underwent stent\u2010percutaneous coronary intervention (PCI) of R\u2010ACAOS because of significant symptoms, positive stress tests, and\/or significant stenosis. Stent\u2010PCI was successful in all cases and correlated with improved symptoms at &gt;1\u2010year follow\u2010up in 30 patients (71%) who were available for clinical follow\u2010up. No ACAOS\u2010related deaths occurred. The instent restenosis rate was 4\/30 (13%) at a mean follow\u2010up time of 5.0 years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This preliminary, but large and unprecedented observational study shows that cases angiographically identified as R\u2010ACAOS universally feature an intramural aortic course but only occasionally severe stenosis on resting IVUS imaging. Our data suggest that stent\u2010PCI with IVUS monitoring ameliorates patients\u2019 presenting symptoms. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26069","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T00:04:24Z","timestamp":1436918664000},"page":"199-208","source":"Crossref","is-referenced-by-count":99,"title":["Origin of the right coronary artery from the opposite sinus of Valsalva in adults: Characterization by intravascular ultrasonography at baseline and after stent angioplasty"],"prefix":"10.1002","volume":"86","author":[{"given":"Paolo","family":"Angelini","sequence":"first","affiliation":[{"name":"Department of Cardiology Texas Heart Institute Houston Texas"},{"name":"Center for Coronary Artery Anomalies Texas Heart Institute Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Uribe","sequence":"additional","affiliation":[{"name":"Center for Coronary Artery 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