{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T21:07:07Z","timestamp":1771708027829,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T00:00:00Z","timestamp":1435017600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the incidence of major adverse cardiac and cerebrovascular events (MACCE) and thrombolysis in myocardial infarction (TIMI) bleedings in primary percutaneous coronary intervention (pPCI) performed through transradial approach (TRA) or transfemoral approach (TFA) with systematic closure by FemoSeal\u2122.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Although the risk of bleeding can be reduced using vascular closure devices (VCD), there are few data comparing TRA and TFA with VCD, particularly in the setting of pPCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>we included in this retrospective registry 777 patients who underwent pPCI at two centers from years 2010 to 2013. Exclusion criteria were implantation of intra\u2010aortic balloon pump and achievement of femoral hemostasis by other means than FemoSeal\u2122. We performed propensity\u2010score matching and multivariate analysis to adjust for clinical and procedural confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We enrolled 511 patients in TRA group and 266 in TFA group. Both in the general population and in the propensity\u2010matched population, the incidence of MACCE was comparable in TRA vs. TFA patients (3.5 vs. 3.4% and 4.4 vs. 2.6%, respectively; <jats:italic>P<\/jats:italic>\u2009=\u2009ns). On the contrary, we observed a higher incidence of TIMI bleedings in TFA vs. TRA patients (5.6 vs. 2.2% in the general population and 6.6 vs. 1.3% in the propensity\u2010matched population; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.05); this difference was mainly driven by TIMI major bleedings. TFA was an independent predictor of bleeding at multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In pPCI the rate of TIMI major bleedings was higher in TFA with closure by FemoSeal\u2122 as compared to TRA, whereas the rates of minor bleedings and of MACCE were similar. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26076","type":"journal-article","created":{"date-parts":[[2015,6,23]],"date-time":"2015-06-23T09:45:39Z","timestamp":1435052739000},"page":"849-854","source":"Crossref","is-referenced-by-count":8,"title":["Transfemoral approach with systematic use of FemoSeal\u2122 closure device compared to transradial approach in primary angioplasty"],"prefix":"10.1002","volume":"87","author":[{"given":"Alessandro","family":"Alonzo","sequence":"first","affiliation":[{"name":"Interventional Cardiology Department of Clinical and Molecular Medicine \u201cSapienza\u201d University of Rome, Sant'Andrea Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Rigattieri","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Sandro Pertini Hospital ASL Roma B Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Giovannelli","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department of Clinical and Molecular Medicine \u201cSapienza\u201d University of Rome, Sant'Andrea Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristian","family":"Di Russo","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Sandro Pertini Hospital ASL Roma B Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Sciahbasi","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Sandro Pertini Hospital ASL Roma B Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Berni","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department of Clinical and Molecular Medicine \u201cSapienza\u201d University of Rome, Sant'Andrea Hospital Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Volpe","sequence":"additional","affiliation":[{"name":"Division of Cardiology Department of Clinical and Molecular Medicine Faculty of Medicine and Psychology, University of Rome Sapienza, Rome, and IRCCS Neuromed, Pozzilli (IS)  Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,6,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs215"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2008.05.007"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I1A12"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.01.162"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.06.017"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.01.161"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I4A78"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu278"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-115-4-256"},{"key":"e_1_2_6_11_1","unstructured":"ThoemmesF.An SPSS R menu for propensity score matching 2011.http:\/\/www.arxiv.org. 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