{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T16:54:47Z","timestamp":1760028887463},"reference-count":19,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:00:00Z","timestamp":1445299200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Tyco Healthcare\/Mallinckrodt, Inc. (St. Louis, Missouri)"},{"name":"Guerbet Group (Paris, France)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Long\u2010term clinical outcomes after exposure to non\u2010ionic iso\u2010osmolar contrast medium (IOCM) or ionic low\u2010osmolar CM (LOCM) in patients with chronic kidney disease (CKD) undergoing coronary angiography are unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The ICON trial was a prospective, double\u2010blinded, multicentre study that randomly assigned 146 patients with CKD undergoing coronary angiography with or without percutaneous coronary intervention to the non\u2010ionic IOCM Iodixanol or the ionic LOCM Ioxaglate. We report the 1\u2010year clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After randomization, baseline and procedural characteristics were well\u2010matched between the two groups. At 1 year, three deaths (4.1%) occurred in the ioxaglate and nine deaths in the iodixanol group (13.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.07). The cardiac death rate at 1 year was 2.7% in the ioxaglate group and 9.1% in the iodixanol group (<jats:italic>P<\/jats:italic>\u2009=\u20090.07). There were no significant differences in the rates of myocardial infarction (1.4% vs. 1.5%; <jats:italic>P<\/jats:italic>\u2009=\u20091.00) and repeated revascularization (6.8% vs. 9.1%; <jats:italic>P<\/jats:italic>\u2009=\u20090.75).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The use of ionic LOCM ioxaglate was associated with a numerically lower mortality at 1 year as compared to iodixanol in patients who underwent cardiac catheterization. Future studies evaluating long\u2010term safety following exposure to different types of CM are warranted. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26106","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T16:43:00Z","timestamp":1445359380000},"page":"703-709","source":"Crossref","is-referenced-by-count":10,"title":["One\u2010year results of the <scp>ICON<\/scp> (ionic versus non\u2010ionic contrast to obviate worsening nephropathy after angioplasty in chronic renal failure patients) Study"],"prefix":"10.1002","volume":"87","author":[{"given":"Gennaro","family":"Giustino","sequence":"first","affiliation":[{"name":"Mount Sinai Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Usman","family":"Baber","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Mastoris","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios J.","family":"Vlachojannis","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Yu","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul S.","family":"Teirstein","sequence":"additional","affiliation":[{"name":"Scripps Clinic San Diego California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William E.","family":"Downey","sequence":"additional","affiliation":[{"name":"Moses Cone Heart and Vascular Center Greensboro North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wayne B.","family":"Batchelor","sequence":"additional","affiliation":[{"name":"St. Michaels Hospital Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter J.","family":"Casterella","sequence":"additional","affiliation":[{"name":"Swedish Heart and Vascular Institute Seattle Washington"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eugenia","family":"Nikolsky","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Chiu","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Medicine Weill\u2010Cornell Medical College New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kleanthis N.","family":"Theodoropoulos","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George D.","family":"Dangas","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.32766"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu063"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5000366"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.595090"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60689-9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.068"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.075"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.05.002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2009.03.007"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021833"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2008.05.023"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.671644"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.06.047"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.874933"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.00550109"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5001887"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2005.00377.x"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2005101085"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa041031"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.26106","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.26106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T18:01:46Z","timestamp":1695751306000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.26106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10,20]]},"references-count":19,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/ccd.26106"],"URL":"https:\/\/doi.org\/10.1002\/ccd.26106","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10,20]]}}}