{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:17:49Z","timestamp":1762298269372},"reference-count":36,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T00:00:00Z","timestamp":1440547200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"University of Kentucky Clinical and Translational Science Pilot Award","award":["UL1TR000117"],"award-info":[{"award-number":["UL1TR000117"]}]},{"name":"UK COBRE Early Career Program","award":["P20 GM103527"],"award-info":[{"award-number":["P20 GM103527"]}]},{"name":"NIH","award":["R56 HL124266"],"award-info":[{"award-number":["R56 HL124266"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Dual antiplatelet therapy (DAPT) is recommended for \u226512 months following coronary drug\u2010eluting stents (DES) to reduce risk of major adverse ischemic events. Randomized trials suggest an abbreviated DAPT duration (\u22646 months) is adequately protective. However, these trials are individually underpowered to detect differences in rare but serious events such as stent thrombosis (ST).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We performed a meta\u2010analysis of published randomized trials to define the impact of abbreviated DAPT (\u22646 months) on death, myocardial infarction (MI), stent thrombosis (ST), and bleeding complications compared to standard\u2010duration DAPT (\u226512 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Seven randomized controlled trials comparing abbreviated vs. standard DAPT regimens following DES use were identified by two independent investigators. Study characteristics were reviewed and clinical endpoint data were abstracted and analyzed in aggregate using fixed and random\u2010effects models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The seven trials included 15,874 randomized patients. Second\u2010generation DES were used in most patients. Compared to standard\u2010duration DAPT, abbreviated DAPT was not associated with an increase in mortality (OR 0.93; CI: 0.73 to 1.17; <jats:italic>P<\/jats:italic>\u2009=\u20090.52), MI (OR 1.14; CI: 0.89 to 1.45; <jats:italic>P<\/jats:italic>\u2009=\u20090.30) or ST (OR 1.25; CI: 0.81 to 1.93; <jats:italic>P<\/jats:italic>\u2009=\u20090.31). Abbreviated DAPT was associated with significantly fewer major bleeding complications (OR 0.52; CI: 0.34 to 0.82; <jats:italic>P<\/jats:italic>\u2009=\u20090.005). The results were consistent between fixed and random\u2010effects models, with no heterogeneity. Sensitivity analyses adjusting for inclusion of bare metal stents, 1st generation DES and\/or abbreviated DAPT regimens of 3 months resulted in similar conclusions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In a meta\u2010analysis of &gt;15,000 patients primarily treated with second\u2010generation DES, abbreviated\u2010duration DAPT (\u22646 months) was associated with a significant reduction in major bleeding complications with no evidence of a significant increase in risk of death, MI or ST. Accordingly, abbreviated DAPT should be strongly considered for patients receiving second generation DES . \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26110","type":"journal-article","created":{"date-parts":[[2015,8,26]],"date-time":"2015-08-26T15:55:53Z","timestamp":1440604553000},"page":"722-732","source":"Crossref","is-referenced-by-count":13,"title":["Safety of an abbreviated duration of dual antiplatelet therapy (\u22646 months) following second\u2010generation drug\u2010eluting stents for coronary artery disease: A systematic review and meta\u2010analysis of randomized trials"],"prefix":"10.1002","volume":"87","author":[{"given":"Khaled M.","family":"Ziada","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine Gill Heart Institute, University of Kentucky, and the Lexington VA Medical Center Lexington 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