{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T23:20:11Z","timestamp":1773876011959,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T00:00:00Z","timestamp":1439424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,2,15]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate long\u2010term survival in high surgical risk patients undergoing percutaneous mitral valve repair (MVR) using the MitraClip<jats:sup>\u00ae<\/jats:sup> system and to identify preprocedural predictors of long\u2010term mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Data for long\u2010term survival and preprocedural predictors of mortality after percutaneous MVR in high surgical risk patients are sporadic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2009 to April 2013, 136 consecutive high surgical risk patients, with symptomatic moderate\u2010to\u2010severe or severe mitral regurgitation (MR), underwent percutaneous MVR using the MitraClip system. Cardiac and overall survival was determined at one and 2 years postprocedure. Univariate and multivariate analysis was performed to identify preprocedural predictors of long\u2010term mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One year postprocedure, cardiac and overall survival was 86.7% and 84.6%, respectively and at 2 years cardiac and overall survival was 77.7% and 74.8%, respectively. In univariate analysis advanced age, lower body mass index, impaired renal function, elevated levels of log\u2010N\u2010terminal\u2010pro\u2010brain\u2010natriuretic\u2010peptide (log\u2010NTproBNP), poor performance in functional tests (New York Heart Association (NYHA) class) and high logistic Euroscore (LES) and Society of Thoracic Surgeons (STS) score were identified as preprocedural predictors of long\u2010term cardiac mortality. In multivariate analysis preoperative NYHA class III and IV, elevated levels of log\u2010NTproBNP and advanced age predicted long\u2010term cardiac mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Percutaneous MVR using the MitraClip system has favorable long\u2010term survival rates in high surgical risk patients. Preprocedural NYHA functional class III and IV, elevated log\u2010NTproBNP levels and advanced age predict higher long\u2010term cardiac mortality and should be considered during patient selection. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26137","type":"journal-article","created":{"date-parts":[[2015,8,13]],"date-time":"2015-08-13T06:57:57Z","timestamp":1439449077000},"page":"467-475","source":"Crossref","is-referenced-by-count":22,"title":["Long\u2010term survival and preprocedural predictors of mortality in high surgical risk patients undergoing percutaneous mitral valve repair"],"prefix":"10.1002","volume":"87","author":[{"given":"Andreas S.","family":"Triantafyllis","sequence":"first","affiliation":[{"name":"Department of Cardiology St. Antonius Hospital Nieuwegein The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Friso","family":"Kortlandt","sequence":"additional","affiliation":[{"name":"Department of Cardiology 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