{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:04:03Z","timestamp":1761987843105,"version":"build-2065373602"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T00:00:00Z","timestamp":1445472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2015,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Laser\u2010assisted balloon angioplasty (LABA) has been shown to be more effective in achieving angiographic success for treatment for below knee peripheral artery disease (PAD) compared with balloon angioplasty alone(BA). However, long\u2010term outcomes of LABA compared with BA for popliteal and infrapopliteal PAD are unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated data on 726 patients undergoing LABA (<jats:italic>n<\/jats:italic>\u2009=\u2009395) and BA (<jats:italic>n<\/jats:italic>\u2009=\u2009331) for popliteal and infrapopliteal PAD retrospectively at a single center (2007\u20132012). Outcomes included long\u2010term ipsilateral major limb amputation, revascularization and mortality (median follow\u2010up\u2009=\u200936 months).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline features were similar in two groups with the exception of more TASC\u2010D lesions (92.4 vs. 66.5%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) and chronic total occlusions (86.4 vs. 49.5%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001) in LABA group. Angiographic success was higher in LABA compared with BA (97.7 vs. 89.2%; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.0001). Ipsilateral major limb amputation (4.1 vs. 5.1%, <jats:italic>P<\/jats:italic>\u2009=\u20090.48) and repeat revascularization (25.1 vs. 23.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.47) were similar in LABA and BA patients despite unfavorable baseline angiographic characteristics in the former. Compared with BA, death was more frequently in LABA group (35.2 and 26.3%, <jats:italic>P<\/jats:italic>\u2009=\u20090.01), a reflection of higher comorbid conditions in this group (adjusted HR 1.05, 95% CI 0.79\u20131.39).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite worse baseline angiographic characteristics compared with BA, LABA was associated with higher angiographic success and similar ipsilateral major amputation, repeat revascularization, and long\u2010term mortality. Future randomized clinical trial should evaluate the efficacy of LABA compared with BA (particularly drug\u2010eluting) in improving limb salvage and reducing repeat revascularization in these high\u2010risk PAD patients. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26145","type":"journal-article","created":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T09:58:47Z","timestamp":1445507927000},"page":"1211-1218","source":"Crossref","is-referenced-by-count":9,"title":["Laser in infrapopliteal and popliteal stenosis 2 study (<scp>LIPS<\/scp>2): Long\u2010term outcomes of laser\u2010assisted balloon angioplasty versus balloon angioplasty for below knee peripheral arterial disease"],"prefix":"10.1002","volume":"86","author":[{"given":"Chatchawan","family":"Piyaskulkaew","sequence":"first","affiliation":[{"name":"St. John Hospital and Medical Center Detroit Michigan (LIPS2 Study Group)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kesav","family":"Parvataneni","sequence":"additional","affiliation":[{"name":"St. John Hospital and Medical Center Detroit Michigan (LIPS2 Study Group)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussein","family":"Ballout","sequence":"additional","affiliation":[{"name":"St. John Hospital and Medical Center Detroit Michigan (LIPS2 Study Group)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Szpunar","sequence":"additional","affiliation":[{"name":"St. John Hospital and Medical Center Detroit Michigan (LIPS2 Study Group)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tarun","family":"Sharma","sequence":"additional","affiliation":[{"name":"St. John Hospital and Medical Center Detroit Michigan (LIPS2 Study Group)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamed","family":"Almahmoud","sequence":"additional","affiliation":[{"name":"Wake Forest Baptist Hospital Winston\u2010Salem North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"LaLonde","sequence":"additional","affiliation":[{"name":"St. John Hospital and Medical Center Detroit Michigan (LIPS2 Study Group)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Davis","sequence":"additional","affiliation":[{"name":"St. John Hospital and Medical Center Detroit Michigan (LIPS2 Study Group)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajendra H.","family":"Mehta","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute and Duke University Medical Center Durham North Carolina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Yamasaki","sequence":"additional","affiliation":[{"name":"St. John Hospital and Medical Center Detroit Michigan (LIPS2 Study Group)"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,10,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccl.2014.09.008"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.174526"},{"key":"e_1_2_7_4_1","first-page":"19","volume-title":"Epidemiological and economic considerations in the critically ischemic limb","author":"Fisher 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