{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T22:45:41Z","timestamp":1759099541329},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"The Medicines Company (Parsippany, New Jersey)"},{"name":"Nycomed, Boston Scientific (Natick, Massachusetts)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,2,15]]},"abstract":"<jats:p><jats:bold><jats:styled-content>Objectives<\/jats:styled-content><\/jats:bold>: We aimed to construct a predictive model for one\u2010year mortality in patients undergoing invasive coronary evaluation and to examine the impact of bivalirudin on survival according to the level of baseline risk.<\/jats:p><jats:p><jats:bold><jats:styled-content>Background<\/jats:styled-content><\/jats:bold>: Compared to heparin plus GP IIb\/IIIa inhibitors (HEP\/GPI), bivalirudin decreases bleeding complications in a range of clinical presentations. The impact of preprocedural risk assessment on survival and whether this is modified by bivalirudin, has not been investigated in detail.<\/jats:p><jats:p><jats:bold><jats:styled-content>Methods<\/jats:styled-content><\/jats:bold>: We examined patient\u2010level data from the REPLACE\u20102, ACUITY, and HORIZONS\u2010AMI trials (<jats:italic>n<\/jats:italic>\u2009=\u200918,819) to construct a risk\u2010adjusted mortality model using baseline clinical variables.<\/jats:p><jats:p><jats:bold><jats:styled-content>Results<\/jats:styled-content><\/jats:bold>: One\u2010year mortality occurred in 287 patients (3.1%) assigned to bivalirudin and 336 patients (3.6%) assigned to HEP\/GPI (HR 0.85; 95% CI, 0.73\u20131.00; <jats:italic>P<\/jats:italic>\u2009=\u20090.048). Using 11 highly significant predictors of mortality, we developed an integer\u2010risk score to classify patients into risk tertiles. High\u2010risk patients had a rate of 1\u2010year mortality over 9\u2010fold greater than low\u2010risk patients. Consequently, the absolute mortality reduction attributed to bivalirudin was more marked in high\u2010risk patients: 3.1% (\u22120.8% to 7.0%) in the overall cohort, 4.8% (0.5% to 9.2%) in the PCI cohort (<jats:italic>P<\/jats:italic>\u2010interaction versus intermediate and low risk categories, 0.09 and <jats:italic>P<\/jats:italic>\u2009=\u20090.02, respectively).<\/jats:p><jats:p><jats:bold><jats:styled-content>Conclusions<\/jats:styled-content><\/jats:bold>: In patients undergoing invasive coronary evaluation, 1\u2010year mortality can be predicted using baseline variables. Bivalirudin treatment (versus HEP\/GPI) conferred a survival benefit. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/ccd.26146","type":"journal-article","created":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T20:06:44Z","timestamp":1449000404000},"page":"391-400","source":"Crossref","is-referenced-by-count":5,"title":["Prediction of 1\u2010year mortality and impact of bivalirudin therapy according to level of baseline risk: A patient\u2010level pooled analysis from three randomized trials"],"prefix":"10.1002","volume":"87","author":[{"given":"Jennifer","family":"Yu","sequence":"first","affiliation":[{"name":"Mount Sinai Medical Center Cardiovascular Institute New York New York"},{"name":"Prince of Wales Hospital Clinical School University of New South Wales  NSW Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Mount Sinai Medical Center Cardiovascular Institute New York New York"},{"name":"Cardiovascular Research Foundation New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"Clayton","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. 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