{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,31]],"date-time":"2026-01-31T04:50:50Z","timestamp":1769835050870,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T00:00:00Z","timestamp":1441152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation of Korea (Basic Science Research Program)"},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"crossref","award":["2012M3A9C7050140"],"award-info":[{"award-number":["2012M3A9C7050140"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"crossref","award":["2012R1A2A2A02012821"],"award-info":[{"award-number":["2012R1A2A2A02012821"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"crossref"}]},{"name":"SNUBH Research Fund","award":["03-2011-011"],"award-info":[{"award-number":["03-2011-011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to evaluate the effect of cigarette smoking on long\u2010term outcomes after successful percutaneous coronary intervention for chronic total occlusion (CTO) lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Cigarette smoking promotes the progression of atherosclerosis but enhances the antiplatelet effect of clopidogrel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Korea National Registry of CTO Intervention included 2,167 patients with CTO lesions from 26 centers who were successfully revascularized with drug\u2010eluting stents from 2007 to 2009. Thrombotic events were defined as the composite of cardiac death, nonfatal myocardial infarction, and stent thrombosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Current\u2010smokers had more favorable baseline characteristics such as a younger age and lower prevalence of hypertension and diabetes mellitus. At 1 year, current\u2010smokers had a significantly lower thrombotic event rate (1.1% vs. 2.7%, <jats:italic>P<\/jats:italic>\u2009=\u20090.034), but a significantly higher target vessel revascularization (TVR) rate (7.2% vs. 4.2%, <jats:italic>P<\/jats:italic>\u2009=\u20090.017) compared with never\u2010smokers. After adjustment, current\u2010smoking was independently associated with a 72% decreased risk for thrombotic events, and 73% increased risk for TVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients with a revascularized CTO lesion, cigarette smoking is associated with fewer thrombotic events but with a higher incidence of TVR. Patients with CTO may benefit from smoking cessation to reduce TVR in conjunction with the use of new more potent antiplatelet agents whose effect is independent of cigarette smoking to improve thrombotic events. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26167","type":"journal-article","created":{"date-parts":[[2015,9,2]],"date-time":"2015-09-02T21:52:38Z","timestamp":1441230758000},"page":"1050-1062","source":"Crossref","is-referenced-by-count":6,"title":["Impact of smoking status on clinical outcomes after successful chronic total occlusion intervention: Korean national registry of CTO intervention"],"prefix":"10.1002","volume":"87","author":[{"given":"Min\u2010Ho","family":"Lee","sequence":"first","affiliation":[{"name":"Cardiovascular Center Soonchunhyang University Hospital Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Joo","family":"Park","sequence":"additional","affiliation":[{"name":"Cardiovascular Center 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