{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,11]],"date-time":"2024-08-11T12:30:19Z","timestamp":1723379419651},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare the efficacy and safety of dual antiplatelet therapy (DAPT) and triple therapy (TT, dual antiplatelet plus warfarin) in patients with myocardial infarction (MI) or PCI with stenting (PCI\u2010S) who also require chronic oral anticoagulation. Background: Recommendations for the optimal antiplatelet\/anticoagulant treatment regimen for patients undergoing PCI\u2010S or MI who also require oral anticoagulation are largely based on evidence from observational studies and expert opinions. Methods: A systematic search was performed for studies comparing TT vs. DAPT in patients post PCI\u2010S or MI and requiring chronic anticoagulation. Primary outcome was all\u2010cause mortality. Secondary outcomes were ischemic stroke, major bleeding, MI, and stent thrombosis. Pooled relative risks (RR) were calculated using random effects model. Results: A total of 17 studies were included, with 14,921 patients [TT: 5,819(39%) and DAPT: 9,102(61%)] and a mean follow\u2010up of 1.6 years. The majority of patients required oral anticoagulation for atrial fibrillation. Compared to DAPT, patients treated with TT had no significant difference in all\u2010cause mortality [RR: 0.81, 95% confidence interval (CI): 0.61\u20131.08, <jats:italic>P<\/jats:italic>\u2009=\u20090.15], MI [RR 0.74, 95% CI: 0.51\u20131.06, <jats:italic>P<\/jats:italic>\u2009=\u20090.10], and stent thrombosis [RR 0.67, 95% CI: 0.35\u20131.30, <jats:italic>P<\/jats:italic>\u2009=\u20090.24]. Patients treated with TT had significantly increased risk of major bleeding [RR 1.20, 95% CI: 1.03\u20131.39, <jats:italic>P<\/jats:italic>\u2009=\u20090.02], whereas the risk for ischemic stroke was significantly lower [RR 0.59, 95% CI: 0.38\u20100.92, <jats:italic>P<\/jats:italic>\u2009=\u20090.02]. Conclusions: All\u2010cause mortality appears similar in patients treated with TT or DAPT although TT was associated with higher rates of major bleeding and a lower risk for ischemic stroke. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26234","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T14:46:42Z","timestamp":1441896402000},"source":"Crossref","is-referenced-by-count":16,"title":["Evaluation of the efficacy and safety of dual antiplatelet therapy with or without warfarin in patients with a clinical indication for DAPT and chronic anticoagulation: A meta\u2010analysis of observational studies"],"prefix":"10.1002","volume":"88","author":[{"given":"Chirag","family":"Bavishi","sequence":"first","affiliation":[{"name":"Mount Sinai St. Luke's and Roosevelt Hospitals New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Koulova","sequence":"additional","affiliation":[{"name":"Mount Sinai St. Luke's and Roosevelt Hospitals New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sripal","family":"Bangalore","sequence":"additional","affiliation":[{"name":"New York University School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashwin","family":"Sawant","sequence":"additional","affiliation":[{"name":"Mount Sinai St. Luke's and Roosevelt Hospitals New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saurav","family":"Chatterjee","sequence":"additional","affiliation":[{"name":"Mount Sinai St. Luke's and Roosevelt Hospitals New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Ather","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham Birmingham Alabama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Valencia","sequence":"additional","affiliation":[{"name":"General Hospital University of Alicante Alicante Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaus","family":"Sarafoff","sequence":"additional","affiliation":[{"name":"Klinikum Der Ludwig\u2010Maximilians\u2010Universit\u00e4t Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Rubboli","sequence":"additional","affiliation":[{"name":"Division of Cardiology Ospedale Maggiore Bologna Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juhani K.","family":"Airaksinen","sequence":"additional","affiliation":[{"name":"Turku University Hospital and University of Turku Heart Center Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory Y. 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