{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:10:40Z","timestamp":1762506640563},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the feasibility and safety of the fourth generation WATCHMAN device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The WATCHMAN left atrial appendage (LAA) closure device has been shown to be non\u2010inferior to conventional oral anticoagulation with warfarin for stroke prevention in patients with non\u2010valvular atrial fibrillation. A new (fourth) generation of the WATCHMAN device was designed to facilitate easier delivery and improve safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a prospective, non\u2010randomized study of LAA closure with use of the 4<jats:sup>th<\/jats:sup> generation WATCHMAN device in 36 patients with non\u2010valvular atrial fibrillation. Follow\u2010up was performed at 45 days, 6 months and 12 months following implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the population was 73\u2009\u00b1\u20096 years and 67% were male. The mean CHADS<jats:sub>2<\/jats:sub> and CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>\u2010VASc Score were 2.5 and 4.5, respectively. The device was implanted successfully in 34\/36 (94%). No serious hospital complications related to the device or procedure occurred. During 12 month follow\u2010up, three ischemic strokes (8%), one hemorrhagic stroke (3%), one TIA (3%) and three deaths (9%) occurred. Device\u2010associated thrombus formation was detected in one patient (3%) during six\u2010month follow\u2010up and was treated successfully with low molecular weight heparin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>LAA closure with the 4<jats:sup>th<\/jats:sup> generation WATCHMAN device is feasible and safe. New technical features may contribute to a better performance of the occluder, particularly regarding the risk of pericardial effusions. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26238","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T14:47:42Z","timestamp":1441896462000},"page":"787-794","source":"Crossref","is-referenced-by-count":2,"title":["Left atrial appendage closure: First in man with the 4th generation watchman device"],"prefix":"10.1002","volume":"87","author":[{"given":"Jakob","family":"Ledwoch","sequence":"first","affiliation":[{"name":"CardioVascular Center CVC Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Franke","sequence":"additional","affiliation":[{"name":"CardioVascular Center CVC Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maik","family":"Gonzaga","sequence":"additional","affiliation":[{"name":"CardioVascular Center CVC Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Bertog","sequence":"additional","affiliation":[{"name":"CardioVascular Center CVC Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annkathrin","family":"Braut","sequence":"additional","affiliation":[{"name":"CardioVascular Center CVC Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ilona","family":"Hofmann","sequence":"additional","affiliation":[{"name":"CardioVascular Center CVC Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Vaskelyte","sequence":"additional","affiliation":[{"name":"CardioVascular Center CVC Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer","family":"Gafoor","sequence":"additional","affiliation":[{"name":"CardioVascular Center CVC Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Reddy","sequence":"additional","affiliation":[{"name":"Mount Sinai School of Medicine New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horst","family":"Sievert","sequence":"additional","affiliation":[{"name":"CardioVascular Center CVC Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs253"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22764"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.089"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.04.029"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61343-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.114389"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.976449"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.03.035"},{"key":"e_1_2_8_10_1","article-title":"Left atrial appendage occlusion for stroke prevention in atrial fibrillation: Multicentre experience with the AMPLATZER Cardiac Plug","volume":"10","author":"Tzikas A","year":"2015","journal-title":"EuroIntervention"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.15192"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp285"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(95)00887-X"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv069"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV6I2A35"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.03.042"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10554-014-0393-0"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.028"},{"key":"e_1_2_8_19_1","unstructured":"ParkJW.Results of the AMPLATZER Cardiac Plug European Multicenter Observational Study. 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