{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T09:40:25Z","timestamp":1695807625744},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T00:00:00Z","timestamp":1441843200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Cardiology, Erasmus MC, Rotterdam, the Netherlands and Department of Cardiology, UMC St Radboud, Nijmegen, the Netherlands"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Whether ischemic postconditioning (IPOC) immediately after routine thrombus aspiration (TA) reduces infarct size (IS) in patients with ST\u2010segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI) has not been established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study design<\/jats:title><jats:p>The POstconditioning Rotterdam Trial (PORT) is a dual\u2010center, prospective, open\u2010label, randomized trial with blinded endpoint evaluation enrolling 72 subjects with first\u2010time STEMI, and an occluded infarct\u2010related artery (IRA) without collaterals undergoing PPCI. Subjects are randomized 1:1 to a strategy of IPOC immediately after TA followed by stenting of the IRA or to conventional percutaneous coronary intervention (PCI), including TA followed by stenting of the IRA (controls). Cardiac magnetic resonance imaging (MRI) is performed at 3\u20135 days after STEMI and at 3 months. The primary endpoint is IS at 3 months measured by delayed enhancement MRI. Other secondary endpoints include MRI\u2010derived microvascular obstruction (MVO), left ventricular ejection fraction, myocardial salvage index, enzymatic IS, ST\u2010segment resolution, myocardial blush grade, microcirculatory resistance, inflammation markers, and clinical events through 3\u2010month follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PORT is testing the hypothesis that adding IPOC (against lethal reperfusion injury) to TA (against distal embolization and MVO) is cardioprotective and reduces ultimate IS in STEMI patients undergoing PPCI (<jats:italic>Dutch Trial Register<\/jats:italic> identifier: NTR4040). \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26239","type":"journal-article","created":{"date-parts":[[2015,9,10]],"date-time":"2015-09-10T14:48:31Z","timestamp":1441896511000},"page":"508-514","source":"Crossref","is-referenced-by-count":2,"title":["Ischemic Postconditioning After Routine Thrombus Aspiration During Primary Percutaneous Coronary Intervention: Rationale and Design of the <scp>PO<\/scp>stconditioning <scp>R<\/scp>otterdam Trial"],"prefix":"10.1002","volume":"88","author":[{"given":"Tuncay","family":"Yetgin","sequence":"first","affiliation":[{"name":"Department of Cardiology Thoraxcenter, Erasmus MC Rotterdam the Netherlands"},{"name":"Interuniversity Cardiology Institute of the Netherlands, ICIN\u2010KNAW Utrecht the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthijs","family":"van Kranenburg","sequence":"additional","affiliation":[{"name":"Department of Cardiology Thoraxcenter, Erasmus MC Rotterdam the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim","family":"ten Cate","sequence":"additional","affiliation":[{"name":"Department of Cardiology UMC St. Radboud Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk 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