{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T23:55:14Z","timestamp":1769212514835,"version":"3.49.0"},"reference-count":40,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T00:00:00Z","timestamp":1447891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["8UL1TR000055\u201003"],"award-info":[{"award-number":["8UL1TR000055\u201003"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Improved strategies for stent\u2010based treatment of coronary artery disease at bifurcations require a greater understanding of artery morphology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>We developed a workflow to quantify morphology in the left main coronary (LMCA), left anterior descending (LAD), and left circumflex (LCX) artery bifurcations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Computational models of each bifurcation were created for 55 patients using computed tomography images in 3D segmentation software. Metrics including cross\u2010sectional area, length, eccentricity, taper, curvature, planarity, branching law parameters, and bifurcation angles were assessed using open\u2010sources software and custom applications. Geometric characterization was performed by comparison of means, correlation, and linear discriminant analysis (LDA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Differences between metrics suggest dedicated or multistent approaches should be tailored for each bifurcation. For example, the side branch of the LCX (i.e., obtuse marginal; OM) was longer than that of the LMCA (i.e., LCXprox) and LAD (i.e., first diagonal; D1). Bifurcation metrics for some locations (e.g., LMCA Finet ratio) provide results and confidence intervals agreeing with prior findings, while revised metric values are presented for others (e.g., LAD and LCX). LDA revealed several metrics that differentiate between artery locations (e.g., LMCA vs. D1, LMCA vs. OM, LADprox vs. D1, and LCXprox vs. D1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results provide a foundation for elucidating common parameters from healthy coronary arteries and could be leveraged in the future for treating diseased arteries. Collectively the current results may ultimately be used for design iterations that improve outcomes following implantation of future dedicated bifurcation stents. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26247","type":"journal-article","created":{"date-parts":[[2015,11,19]],"date-time":"2015-11-19T11:50:56Z","timestamp":1447933856000},"page":"1244-1255","source":"Crossref","is-referenced-by-count":17,"title":["Image\u2010based quantification of 3D morphology for bifurcations in the left coronary artery: Application to stent design"],"prefix":"10.1002","volume":"87","author":[{"given":"Laura","family":"Ellwein","sequence":"first","affiliation":[{"name":"Department of Mathematics and Applied Mathematics Virginia Commonwealth University Richmond VA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Marks","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Medical College of Wisconsin Milwaukee Wisconsin"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond Q.","family":"Migrino","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Medical College of Wisconsin Milwaukee Wisconsin"},{"name":"Department of Medicine, VA Health Care System Phoenix Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. 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