{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:00:34Z","timestamp":1760299234658},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,10,22]],"date-time":"2015-10-22T00:00:00Z","timestamp":1445472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims to investigate the association of moderate chronic kidney disease (CKD) with fractional flow reserve (FFR) after stent implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Patients with moderate CKD have a higher prevalence of severe and diffuse coronary artery disease, and have increased risk of cardiovascular events even after stent implantation. On the other hand, in some patients, FFR could not be sufficiently improved even after stent implantation. However, the association between these pathophysiological processes is unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>A total of 102 patients with stable angina, in whom a stent was implanted for the left anterior descending coronary artery (LAD) lesion, were included. Patients with a severely decreased glomerular filtration rate (GFR;\u2009&gt;\u2009CKD stage 4) were excluded. Patients were stratified into 3 groups: those with an estimated GFR (eGFR)\u2009\u2265\u200960 mL per min per 1.73 m<jats:sup>2<\/jats:sup> (stage 0\u20102), 45 to 59 mL per min per 1.73 m<jats:sup>2<\/jats:sup> (stage 3a), and 30 to 44 mL per min per 1.73 m<jats:sup>2<\/jats:sup> (stage 3b). FFR after stent implantation (post\u2010stent FFR) was significantly lower in the stage 3b group than in both the stage 0\u20102 group and the stage 3a group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Post\u2010stent FFR had a significant positive correlation with eGFR (<jats:italic>r<\/jats:italic>\u2009=\u20090.223, <jats:italic>P<\/jats:italic>\u2009=\u20090.024). Multivariate analysis demonstrated that eGFR was an independent predictor of post\u2010stent FFR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Moderate CKD was independently associated with insufficient improvement of FFR after stent implantation. This can partly explain the poor prognosis of patients with CKD. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26258","type":"journal-article","created":{"date-parts":[[2015,10,23]],"date-time":"2015-10-23T11:35:43Z","timestamp":1445600143000},"source":"Crossref","is-referenced-by-count":5,"title":["Association of moderate chronic kidney disease with insufficient improvement of fractional flow reserve after stent implantation"],"prefix":"10.1002","volume":"88","author":[{"given":"Kunihiro","family":"Sakoda","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Tokyo Medical University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine Tokyo Medical University  Tokyo 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