{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T19:47:39Z","timestamp":1780343259412,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T00:00:00Z","timestamp":1447804800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,2,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter mitral valve implantation (TMVI) for severely calcified native mitral valve disease recently emerged as a treatment option in patients deemed inoperable by conventional techniques. Yet no systematic appraisal currently exists characterizing this novel treatment paradigm.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature review summarizing the clinical, anatomical, peri\u2010 and post\u2010procedural characteristics underscoring the technical feasibility of this procedure was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine publications describing 11 patients [mean age 68\u2009\u00b1\u200910 years, 82% female, 82% severe mitral stenosis (MS), 18% severe mitral regurgitation (MR)] were identified. Mean STS score, trans\u2010mitral gradient and effective orifice area were 10.5\u2009\u00b1\u20094.6%, 12\u2009\u00b1\u20092.4 mm Hg and 0.93\u2009\u00b1\u20090.06 cm<jats:sup>2<\/jats:sup> respectively. All patients had severe, circumferential mitral annular calcification on imaging. Dedicated balloon\u2010expanding transcatheter aortic valves were used in 10\/11 cases, with 8\/11 cases involving a true percutaneous approach with peri\u2010procedural 3D trans\u2010esophageal echocardiographic guidance; 3\/11 cases involved an open left atrial approach. Following initial balloon inflation and valve deployment, procedural success rate was 73%, without residual paravalvular leaks (PVL). Successful immediate re\u2010deployment of a 2nd valve was needed in 2 instances following significant PVL detection. Residual trans\u2010valvular gradients ranged from 3 to 7 mm Hg, with no patient demonstrating &gt;grade 2 MR. All patients survived the procedure, with 2 reported deaths on days 10\u2010 and 41 post\u2010TMVI being non\u2010cardiac\u2010related. Mid\u2010term clinical follow\u2010up, reported in 8 patients, revealed 6 patients to be alive at 3\u2010months with much improved functional status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>TMVI for native severely calcified mitral valve disease appears technically feasible with acceptable initial acute and mid\u2010term hemodynamic and clinical outcomes. The outcomes of an ongoing, dedicated global Sapien TMVI registry will shed further light on this evolving treatment paradigm. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26262","type":"journal-article","created":{"date-parts":[[2015,11,18]],"date-time":"2015-11-18T10:34:43Z","timestamp":1447842883000},"page":"540-548","source":"Crossref","is-referenced-by-count":18,"title":["Transcatheter mitral valve implantation for inoperable severely calcified native mitral valve disease: A systematic review"],"prefix":"10.1002","volume":"87","author":[{"given":"Rishi","family":"Puri","sequence":"first","affiliation":[{"name":"Quebec Heart and Lung Institute Quebec City Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Abdul\u2010Jawad Altisent","sequence":"additional","affiliation":[{"name":"Quebec Heart and Lung Institute Quebec City Quebec 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