{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T10:25:02Z","timestamp":1769163902594,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We aimed to assess the association between arterial hypertension and bleeding in patients undergoing percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The impact of arterial hypertension on bleeding risk of patients with coronary artery disease undergoing PCI is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study included 14,180 patients who underwent PCI. Bleeding was defined using the Bleeding Academic Research Consortium (BARC) criteria. Arterial hypertension was defined as treatment with antihypertensive drugs or a systolic blood pressure &gt;140 mm Hg and\/or diastolic blood pressure value &gt;90 mm Hg documented on at least 2 occasions. The primary outcome was bleeding rate within 30 days of PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 11,066 patients (78.0%) had arterial hypertension. Bleeding events occurred in 1,232 patients with arterial hypertension and 278 patients without arterial hypertension (11.1% vs 8.9%; odds ratio [OR]\u2009=\u20091.28, 95% confidence interval [CI] 1.11\u20131.46, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Access\u2010site bleeding occurred in 730 patients with arterial hypertension and 175 patients without arterial hypertension (6.6% vs 5.6%: OR\u2009=\u20091.19 [1.01\u20131.41], <jats:italic>P<\/jats:italic>\u2009=\u20090.049). Non\u2010access\u2010site bleeding occurred in 502 patients with and 103 patients without arterial hypertension (4.5% vs 3.3%; OR\u2009=\u20091.39 [1.12\u20131.72], <jats:italic>P<\/jats:italic>\u2009=\u20090.003). After adjustment, arterial hypertension was significantly associated with any bleeding (adjusted OR\u2009=\u20091.41 [1.19\u20131.67], <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), access\u2010site bleeding (adjusted OR\u2009=\u20091.36 [1.10\u20131.68], <jats:italic>P<\/jats:italic>\u2009=\u20090.005) and non\u2010access\u2010site bleeding (adjusted OR\u2009=\u20091.42 [1.09\u20131.83], <jats:italic>P<\/jats:italic>\u2009=\u20090.008). A history of arterial hypertension increased the risk of non\u2010access\u2010site bleeding (<jats:italic>P<\/jats:italic>\u2009=\u20090.002), whereas systolic blood pressure at the time of PCI increased the risk of access site bleeding (<jats:italic>P<\/jats:italic>\u2009=\u20090.018).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Arterial hypertension is associated with increased risk of bleeding during PCI procedures. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26272","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T12:02:58Z","timestamp":1446552178000},"page":"184-190","source":"Crossref","is-referenced-by-count":9,"title":["Increased bleeding risk during percutaneous coronary interventions by arterial hypertension"],"prefix":"10.1002","volume":"88","author":[{"given":"Gjin","family":"Ndrepepa","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp","family":"Groha","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna L.","family":"Lahmann","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raphaela","family":"Lohaus","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Cassese","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefanie","family":"Schulz\u2010Sch\u00fcpke","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian","family":"Kufner","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina","family":"Mayer","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum M\u00fcnchen, Technische Universit\u00e4t Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabell","family":"Bernlochner","sequence":"additional","affiliation":[{"name":"1.Medizinische Klinik, Klinikum rechts der Isar, Technische Universit\u00e4t Munich Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert 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