{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:51:50Z","timestamp":1768009910774,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>This study sought to assess the long\u2010term clinical benefits and predictors of survival of trans\u2010catheter aortic valve closure in left ventricular assist device (LVAD) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>LVADs have been shown to increase survival and quality of life in patients with end\u2010stage heart failure. However, severe aortic insufficiency (AI) can develop in up to 50% of patients at 12 months resulting in significant morbidity and mortality. Trans\u2010catheter treatment of LVAD associated AI has emerged as a potential alternative to surgical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a retrospective analysis of all patients undergoing trans\u2010catheter aortic valve closure using an Amplatzer Multi\u2010Fenestrated Septal Occluder \u201cCribriform\u201d device to assess potential clinical and procedural factors associated with survival. Student's <jats:italic>t<\/jats:italic>\u2010tests were used to compare baseline patient demographics and procedural characteristics, as well as patient outcomes immediately post procedure and at 6 months. A <jats:italic>P<\/jats:italic>\u2010value of less than 0.05 was considered statistically significant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10 patients (70% male, median age 59 years) were included. Technical success was accomplished in 100% of patients with a 6 month survival rate of 30% (3\/10). Compared with survivors, non\u2010survivors had a higher rate of pre\u2010procedural clinical co\u2010morbidities, an increased likelihood of right ventricular failure, and received larger occluder devices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Trans\u2010catheter aortic valve closure successfully treats late severe AI in LVAD patients, however, the presence or development of right heart failure portends a worse prognosis. Further studies are needed to investigate the factors involved in the development of right ventricular failure, and potential treatment, in patients undergoing trans\u2010catheter aortic valve closure. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26280","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T11:24:41Z","timestamp":1446549881000},"page":"971-979","source":"Crossref","is-referenced-by-count":19,"title":["Predictors of survival following trans\u2010catheter aortic valve closure for left ventricular assist device associated aortic insufficiency"],"prefix":"10.1002","volume":"87","author":[{"given":"Elizabeth M.","family":"Retzer","sequence":"first","affiliation":[{"name":"Section of Cardiology, Department of Medicine The University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel T.","family":"Sayer","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine The University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Savitri E.","family":"Fedson","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine The University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Nathan","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine The University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valluvan","family":"Jeevanandam","sequence":"additional","affiliation":[{"name":"Section of Cardiothoracic Surgery, Department of Surgery The University of Chicago Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet","family":"Friant","sequence":"additional","affiliation":[{"name":"Section of Cardiology, Department of Medicine The University of Chicago 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