{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T00:43:32Z","timestamp":1771461812157,"version":"3.50.1"},"reference-count":15,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T00:00:00Z","timestamp":1445990400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The objective of this study is to describe and compare the use of the MitraClip therapy in mitral regurgitation (MR) patients with degenerative MR (DMR) and functional MR (FMR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Percutaneous edge\u2010to\u2010edge repair of severe MR using the MitraClip device is approved for use in the USA for high risk DMR while European guidelines include its use in FMR patients as well.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The <jats:bold>M<\/jats:bold>itraClip in the <jats:bold>A<\/jats:bold>sia\u2010Pacific <jats:bold>R<\/jats:bold>egi<jats:bold>s<\/jats:bold>try (MARS) is a multicenter retrospective registry, involving eight sites in five Asia\u2010Pacific countries. Clinical and echocardiographic characteristics, procedural outcomes and 1\u2010month outcomes [death and major adverse events (MAE)] were compared between FMR and DMR patients treated with the MitraClip.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 163 patients were included from 2011 to 2014. The acute procedural success rates for FMR (95.5%, <jats:italic>n<\/jats:italic>\u2009=\u200984) and DMR (92%, <jats:italic>n<\/jats:italic>\u2009=\u200969) were similar (<jats:italic>P<\/jats:italic>\u2009=\u20090.515). 45% of FMR had \u22652 clips inserted compared to 60% of those with DMR (<jats:italic>P<\/jats:italic>\u2009=\u20090.064).The 30\u2010day mortality rate for FMR and DMR was similar at 4.5% and 6.7% respectively (<jats:italic>P<\/jats:italic>\u2009=\u20090.555). The 30\u2010day MAE rate was 9.2% for FMR and 14.7% for DMR (<jats:italic>P<\/jats:italic>\u2009=\u20090.281). Both FMR and DMR patients had significant improvements in the severity of MR and NYHA class after 30 days. There was a significantly greater reduction in left ventricular end\u2010diastolic diameter (<jats:italic>P<\/jats:italic>\u2009=\u20090.002) and end systolic diameter (<jats:italic>P<\/jats:italic>\u2009=\u20090.017) in DMR than in FMR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The MitraClip therapy is a safe and efficacious treatment option for both FMR and DMR. Although, there is a significantly greater reduction in LV volumes in DMR, patients in both groups report clinical benefit with improvement in functional class. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26289","type":"journal-article","created":{"date-parts":[[2015,10,28]],"date-time":"2015-10-28T10:58:39Z","timestamp":1446029919000},"source":"Crossref","is-referenced-by-count":16,"title":["The MitraClip Asia\u2010Pacific registry: Differences in outcomes between functional and degenerative mitral regurgitation"],"prefix":"10.1002","volume":"87","author":[{"given":"Edgar","family":"Tay","sequence":"first","affiliation":[{"name":"Department of Cardiology National University Heart Centre  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nasir","family":"Muda","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institut Jantung Negara Kuala Lumpur 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Zhejiang University School of Medicine Zhejiang Province People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric","family":"Yamen","sequence":"additional","affiliation":[{"name":"Department of Cardiology Sir Charles Gairdner Hospital Perth Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Jansz","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery St Vincent's Hospital Sydney Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Yip","sequence":"additional","affiliation":[{"name":"Department of Cardiology National University Heart Centre  Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robaayah","family":"Zambahari","sequence":"additional","affiliation":[{"name":"Department of Cardiology Institut Jantung Negara Kuala Lumpur 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Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amiliana M.","family":"Soesanto","sequence":"additional","affiliation":[{"name":"Department of Cardiology National Cardiovascular Center Harapan Kita Jakarta Indonesia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khung Keong","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Cardiology National Heart Centre Singapore  Singapore"},{"name":"Duke\u2010NUS Graduate Medical School  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