{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T03:28:06Z","timestamp":1785554886408,"version":"3.56.0"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T00:00:00Z","timestamp":1446508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Our objective was to perform an updated systematic review to compare the efficacy and short\u2010 and long\u2010term mortality of surgical myectomy (SM) and alcohol septal ablation (ASA) by including most recent and largest cohort studies published in last few years. Background: SM and ASA are the two invasive strategies used to relieve left ventricular outflow tract obstruction (LVOTO) in patients with drug refractory symptomatic hypertrophic cardiomyopathy (HCM). In the absence of a randomized trial, we tried to compare the pros and cons of the two procedures using a systematic review and meta\u2010analysis. Method: A comprehensive search of three major databases was performed. We included original research studies comparing data on ASA and SM. Of 1,143 citations, 10 studies were included in the analysis. Results: A total of 805 patients underwent ASA and 1,019 underwent SM. Patients undergoing SM were younger (MD 6.3, P\u2009=\u20090.0001) and had higher reduction in the LVOT gradient (MD \u22129.56, P\u2009=\u20090.05). However, there was similar resolution of class III and IV symptoms between the two groups (P\u2009=\u20090.56). There was no difference in sudden cardiac death (SCD) (P\u2009=\u20090.93), short\u2010term (P\u2009=\u20090.36), long\u2010term all cause (P\u2009=\u20090.27), and long\u2010term cardiac mortality (P\u2009=\u20090.58). Patients undergoing ASA had higher incidence of post procedure device implantation (OR 3.09, P\u2009&lt;\u20090.00001). Conclusion: No significant difference in symptom relief was noted between the two approaches. ASA was as safe a myectomy with regards to SCD, short\u2010term, and long\u2010term mortality. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26293","type":"journal-article","created":{"date-parts":[[2015,11,3]],"date-time":"2015-11-03T11:28:55Z","timestamp":1446550135000},"page":"107-115","source":"Crossref","is-referenced-by-count":39,"title":["A meta analysis of current status of alcohol septal ablation and surgical myectomy for obstructive hypertrophic cardiomyopathy"],"prefix":"10.1002","volume":"88","author":[{"given":"Kuljit","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Cardiology University of Ottawa Heart Institute Ottawa Ontario K1Y 1J7 Canada"},{"name":"Department of Cardiology Basil Hetzel Institution, University of Adelaide  SA 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Qutub","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Ottawa Heart Institute Ottawa Ontario K1Y 1J7 Canada"},{"name":"Department of Medicine King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Carson","sequence":"additional","affiliation":[{"name":"Department of Cardiology Basil Hetzel Institution, University of Adelaide  SA 5000 Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Hibbert","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Ottawa Heart Institute Ottawa Ontario K1Y 1J7 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Glover","sequence":"additional","affiliation":[{"name":"Department of Cardiology University of Ottawa Heart Institute Ottawa Ontario K1Y 1J7 Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,11,3]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa021332"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu284"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.040"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.076257"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.06.012"},{"key":"e_1_2_5_7_1","article-title":"Long\u2010term outcomes of septal reduction for obstructive hypertrophic cardiomyopathy","author":"Sedehi D","journal-title":"J Cardiol"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2010.02.007"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi042"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1532\/HSF98.20071136"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(01)01656-4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/euhj.2002.3285"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25134"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivs352"},{"key":"e_1_2_5_15_1","first-page":"296","article-title":"Transcoronary ablation of septal hypertrophy compared with surgery in the treatment of hypertrophic obstructive cardiomyopathy","volume":"117","author":"Jiang TY","year":"2004","journal-title":"Chin Med J"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.05.018"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.26293","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.26293","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T03:15:03Z","timestamp":1696648503000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.26293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,3]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2016,7]]}},"alternative-id":["10.1002\/ccd.26293"],"URL":"https:\/\/doi.org\/10.1002\/ccd.26293","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,11,3]]}}}