{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T06:14:03Z","timestamp":1761718443564},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T00:00:00Z","timestamp":1448409600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Boston Scientific, Biosensors International, The Medicines Company, and Edwards Lifesciences"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The influence of age upon the use of drug\u2010eluting stents (DES) in patients aged\u2009\u2265\u200965 years is uncertain. The aim of this study is to investigate the impact of age increase in patients aged\u2009\u2265\u200965 years in the use of DES in patients undergoing percutaneous coronary intervention (PCI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The study cohort comprised 8,598 patients\u2009\u2265\u200965 years of age who underwent stent implantation from April 2003 to March 2014. We defined the first DES era as the period April 2003 to July 2008 and the second DES era as the period July 2008 to March 2014. Multivariable logistic regression was performed for both eras to assess the impact of age increase and analyze independent factors associated with DES implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the first DES era cohort, the two groups of patients differed in their risk factor profile with lower rates of male sex, diabetes, smokers, and hypercholesterolemia in those aged\u2009\u2265\u200975 years. There were more Caucasian and less African\u2010Americans in this age group. Furthermore, patients aged\u2009\u2265\u200975 years had lower left ventricular ejection fraction (LVEF) and baseline haematocrit concentration were more likely to present with an acute myocardial infarction (MI) than stable or unstable angina and had higher rates of a previous history for congestive heart failure (CHF), chronic renal insufficiency (CRI), and peripheral vascular disease (PVD). These differences were broadly similar for patients in the second DES era except for similarities in LVEF, presentation with unstable angina, and PVD, as well as a lower rate for previous PCI. DES use was reduced with increasing age in both the first (OR=0.78; 95% CI=0.69\u20130.89) and second DES era (OR=0.53; 95% CI=0.47\u20130.58). In both eras, DES use was less likely in current smokers, patients presenting with acute MI and cardiogenic shock, and those with a previous history of CHF.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients aged\u2009\u2265\u200965 years, the use of DES decreased with increasing age. This observation was apparent in both the first and second DES era. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26333","type":"journal-article","created":{"date-parts":[[2015,11,25]],"date-time":"2015-11-25T12:34:16Z","timestamp":1448454856000},"page":"516-521","source":"Crossref","is-referenced-by-count":6,"title":["The influence of advancing age on implantation of drug\u2010eluting stents"],"prefix":"10.1002","volume":"88","author":[{"given":"Wenjie","family":"Tian","sequence":"first","affiliation":[{"name":"Section of Interventional Cardiology MedStar Washington Hospital Center  Washington, District of Columbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Section of Cardiovascular Sciences University of Surrey, Guildford, Surrey GU2\u20107XH United 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