{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:37:09Z","timestamp":1774582629171,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T00:00:00Z","timestamp":1452902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL098129 in 2012; UL1 TR000038 in 2013 (to Binita Shah)"],"award-info":[{"award-number":["T32HL098129 in 2012; UL1 TR000038 in 2013 (to Binita Shah)"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000862","name":"Doris Duke Charitable Foundation","doi-asserted-by":"publisher","award":["2010055"],"award-info":[{"award-number":["2010055"]}],"id":[{"id":"10.13039\/100000862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To determine how two different types of iodinated contrast media (CM), low\u2010osmolar ionic dimer ioxaglate (Hexabrix) and iso\u2010osmolar non\u2010ionic dimer iodixanol (Visipaque), affect multiple indices of hemostasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p><jats:italic>In vitro<\/jats:italic> models demonstrate differential effects of ionic and non\u2010ionic CM on markers of hemostasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This blinded endpoint trial randomized 100 patients to ioxaglate or iodixanol. The primary endpoint was change in endogenous thrombin potential (ETP) following diagnostic angiography. Secondary endpoints included change in markers of fibrinolysis [tissue plasminogen activator (tPA) and plasminogen activator inhibitor 1 (PAI\u20101)] and platelet aggregation following diagnostic angiography and percutaneous coronary intervention (PCI) with bivalirudin. Data are presented as median [interquartile range].<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>ETP significantly decreased after diagnostic angiography in both ioxaglate (baseline 1810 nM*minute [1540\u20102089] to post\u2010angiography 649 nM*minute [314\u20101347], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and iodixanol groups (baseline 1682 nM*minute [1534\u20102147] to post\u2010angiography 681 nM*minute [229\u20101237], <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but the decrease was not different between CM (<jats:italic>p<\/jats:italic>\u2009=\u20090.70). There was a significant increase in ETP during PCI (<jats:italic>n<\/jats:italic>\u2009=\u200945), despite the use of bivalirudin, suggesting a prothrombotic effect of PCI (post\u2010angiography 764 nM*minute [286\u20101283] to post\u2010PCI 1081 nM*minute [668\u20101552], <jats:italic>p<\/jats:italic>\u2009=\u20090.02). There were no significant differential effects on tPA, PAI\u20101, and markers of platelet activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were no significant differential effects between ioxaglate and iodixanol. Both CM led to significant reductions in thrombin generation and no significant effects on fibrinolytic activity or platelet activity, thereby contributing to a favorable antithrombotic milieu. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26353","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T22:05:37Z","timestamp":1452981937000},"page":"727-737","source":"Crossref","is-referenced-by-count":2,"title":["The assessment of thrombotic markers utilizing ionic versus non\u2010ionic contrast during coronary angiography and intervention trial"],"prefix":"10.1002","volume":"88","author":[{"given":"Binita","family":"Shah","sequence":"first","affiliation":[{"name":"Department of Medicine (Cardiology) NYU School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey S.","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology and 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York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana","family":"Perez","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) NYU School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Attubato","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) NYU School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Slater","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) NYU School of Medicine New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frederick","family":"Feit","sequence":"additional","affiliation":[{"name":"Department of Medicine (Cardiology) NYU School of Medicine New York New 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