{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T21:54:17Z","timestamp":1757454857141},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T00:00:00Z","timestamp":1451433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare drug\u2010eluting balloons (DEBs) versus second\u2010generation DES in the treatment of drug\u2010eluting stent restenosis (DES\u2010ISR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>The optimal treatment of DES\u2010ISR remains unclear. Several modes of treatment ranging from plain\u2010old balloon angioplasty to repeated use of DES have yielded disappointing results. DEBs are increasingly been used in restenotic lesions; however, their use in DES\u2010ISR is less established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We evaluated all procedures between 2009 and 2011, involving DES\u2010ISR that were treated either with DEB or second\u2010generation DES. The measured end\u2010points during the follow\u2010up period were cardiac\u2010death, target\u2010vessel MI, TLR, TVR, and MACE defined as composite of cardiac\u2010death, TV\u2010MI, and TVR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two hundred and forty\u2010seven patients (302 lesions) with DES\u2010ISR were treated with either DEB (81 patients; 104 lesions) or second\u2010generation DES (166 patients; 198 lesions). The mean age of patients was 66.1\u00a0\u00b1\u00a09.4\u00a0years. There were higher numbers of patients with diabetes in the DEB group (DEB 47% vs DES 33%; p\u00a0=\u00a00.03). The mean length of DEB was significantly longer than the DES (35.4 vs 19.8\u00a0mm; p\u00a0&lt;\u00a00.001). During the 12\u2010month follow\u2010up, there were no significant differences in the MACE rates (12.3% vs 8.4%; p\u00a0=\u00a00.3) and TLR rates (9.9% vs 7.8%; p\u00a0=\u00a00.6) between DEB and DES, respectively. On the multivariate analysis, use of DEB or DES was not the predictor of MACE (hazard ratio: 0.84, 95% CI: 0.46\u20131.85; p\u00a0=\u00a00.6). There were no cases of definite or probable stent thrombosis in either group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>There were no significant differences in the clinical outcomes between DEB and second\u2010generation DES in the treatment of DES\u2010ISR. These results should encourage operators to consider DEB in the treatment of DES\u2010ISR, which offers certain advantages over DES. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26368","type":"journal-article","created":{"date-parts":[[2015,12,30]],"date-time":"2015-12-30T10:46:45Z","timestamp":1451472405000},"page":"522-528","source":"Crossref","is-referenced-by-count":11,"title":["Treatment of drug\u2010eluting stent restenosis: Comparison between drug\u2010eluting balloon versus second\u2010generation drug\u2010eluting stents from a retrospective observational study"],"prefix":"10.1002","volume":"88","author":[{"given":"Sandeep","family":"Basavarajaiah","sequence":"first","affiliation":[{"name":"Heart of England NHS Trust Birmingham United Kingdom"},{"name":"EMO\u2010GVM Centro Cuore Columbus Milan Italy"},{"name":"San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Naganuma","sequence":"additional","affiliation":[{"name":"EMO\u2010GVM Centro Cuore Columbus Milan Italy"},{"name":"San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Azeem","family":"Latib","sequence":"additional","affiliation":[{"name":"EMO\u2010GVM Centro Cuore Columbus Milan Italy"},{"name":"San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandro","family":"Sticchi","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Ciconte","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilis","family":"Panoulas","sequence":"additional","affiliation":[{"name":"EMO\u2010GVM Centro Cuore Columbus Milan Italy"},{"name":"San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaide","family":"Chieffo","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauro","family":"Carlino","sequence":"additional","affiliation":[{"name":"San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Colombo","sequence":"additional","affiliation":[{"name":"EMO\u2010GVM Centro Cuore Columbus Milan Italy"},{"name":"San Raffaele Scientific Institute Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,30]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.10.1215"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.562421"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2005.01.039"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035071"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012843"},{"key":"e_1_2_10_7_1","first-page":"391","article-title":"Predictor of subsequent target lesion revascularization in patients with drug\u2010eluting stent restenosis undergoing percutaneous coronary intervention","volume":"55","author":"Takasawa Y","year":"2010","journal-title":"J Am Coll Cardiol"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.110.946939"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.07.028"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.4244\/V5I3A55"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.02.009"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2012.03.017"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV5I6A116"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2006.12.009"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq277"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.01.015"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.10.012"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(12)61964-3"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2007.09.011"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2010.09.027"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2008.09.107"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.02.046"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-302945"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.936922"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.201376"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.07.069"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25072"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.04.063"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.26368","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.26368","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.26368","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T16:23:00Z","timestamp":1695745380000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.26368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,30]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1002\/ccd.26368"],"URL":"https:\/\/doi.org\/10.1002\/ccd.26368","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,30]]}}}