{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:31:28Z","timestamp":1761863488018},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T00:00:00Z","timestamp":1450828800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,11,15]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Years after mitral valve surgery, progressive degeneration of reconstructed mitral valves or bioprostheses might lead to severe mitral valve regurgitation. Patients with significant comorbidity, or impaired left ventricular function are poor candidates for redo surgery at an acceptable risk at that later time point.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>This study reports the first\u2010in\u2010man transapical valve\u2010in\u2010ring implantations in the mitral position of the fully repositionable Lotus valve system approved for transcatheter aortic valve replacement in Europe. Transapical valve\u2010in\u2010ring implantations with this valve system were successfully performed in a 64\u2010year\u2010old female, and a 53\u2010year\u2010old male patient. Both patients were NHYA class IV, and carried an unacceptably high risk of cardiac surgery due to clinical condition and comorbidity. The first patient was successfully implanted a 25 mm valve, improved to NYHA class II, and was discharged 2\u00a0weeks after the procedure. The second patient required a short episode of cardiopulmonary resuscitation after valve implantation (27 mm), and was placed on veno\u2010venous ECMO for 24 hr to improve oxygenation. He developed stroke on day 7, and deceased from fatal, toxic rhabdomyolysis 13 days after the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Transapical valve\u2010in\u2010ring implantation of the repositionable Lotus valve system in the mitral position is a feasible and promising option that merits further evaluation. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26376","type":"journal-article","created":{"date-parts":[[2015,12,23]],"date-time":"2015-12-23T13:43:03Z","timestamp":1450878183000},"source":"Crossref","is-referenced-by-count":3,"title":["Transcatheter valve\u2010in\u2010ring implantation of a repositionable valve system for treatment of severe mitral regurgitation"],"prefix":"10.1002","volume":"88","author":[{"given":"Michael","family":"Lauterbach","sequence":"first","affiliation":[{"name":"3rd Medical Clinic \u2013 Cardiology, Krankenhaus Der Barmherzigen Br\u00fcder Trier, Nordallee 1, 54296 Trier, Germany a Teaching Affiliate of the University Medical Center Mainz  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Sontag","sequence":"additional","affiliation":[{"name":"3rd Medical Clinic \u2013 Cardiology, Krankenhaus Der Barmherzigen Br\u00fcder Trier, Nordallee 1, 54296 Trier, Germany a Teaching Affiliate of the University Medical Center Mainz  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandros","family":"Paraforos","sequence":"additional","affiliation":[{"name":"Department of Heart, Vascular and Thoracic Surgery, Krankenhaus Der Barmherzigen Br\u00fcder Trier, Nordallee 1, 54296 Trier, Germany a Teaching Affiliate of the University Medical Center Mainz  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivar","family":"Friedrich","sequence":"additional","affiliation":[{"name":"Department of Heart, Vascular and Thoracic Surgery, Krankenhaus Der Barmherzigen Br\u00fcder Trier, Nordallee 1, 54296 Trier, Germany a Teaching Affiliate of the University Medical Center Mainz  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Eugen","family":"Hauptmann","sequence":"additional","affiliation":[{"name":"3rd Medical Clinic \u2013 Cardiology, Krankenhaus Der Barmherzigen Br\u00fcder Trier, Nordallee 1, 54296 Trier, Germany a Teaching Affiliate of the University Medical Center Mainz  Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0195-668X(03)00201-X"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm001"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt155"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1208"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.01.058"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.001607"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"e_1_2_6_9_1","doi-asserted-by":"crossref","first-page":"53","DOI":"10.15420\/icr.2012.7.1.53","article-title":"Transcatheter aortic valve implantation in the hybrid catheterisation laboratory\u2014Navigating into the future","volume":"7","author":"Lauterbach M","year":"2012","journal-title":"Interv Cardiol"},{"key":"e_1_2_6_10_1","first-page":"5494","article-title":"Treating severe aortic valve regurgitation with TAVI","volume":"20","author":"Lauterbach M","year":"2014","journal-title":"Exp Clin Cardiol"},{"key":"e_1_2_6_11_1","first-page":"134","article-title":"Concomitant use of simvastatin and amiodarone resulting in severe rhabdomyolysis: A case report and review of the literature","volume":"66","author":"Marot A","year":"2011","journal-title":"Acta Clin Belg"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2012-002040"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1253\/jcj.62.305"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2006.09.019"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1253\/circj.CJ-12-1433"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.10.013"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv167"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.26376","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.26376","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.26376","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T17:13:29Z","timestamp":1696612409000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.26376"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,23]]},"references-count":16,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2016,11,15]]}},"alternative-id":["10.1002\/ccd.26376"],"URL":"https:\/\/doi.org\/10.1002\/ccd.26376","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,23]]}}}