{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T13:46:42Z","timestamp":1777124802943,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2016,1,17]],"date-time":"2016-01-17T00:00:00Z","timestamp":1452988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The PEPCAD China ISR trial investigated the safety and efficacy of paclitaxel\u2010coated balloon (PCB) angioplasty in an Asian patient population with coronary drug\u2010eluting stent in\u2010stent restenosis (DES\u2010ISR). Methods: A total of 220 patients with coronary DES\u2010ISR were treated with PCB angioplasty or with paclitaxel\u2010eluting stents (PES). This randomized (1:1), single\u2010blind prospective multicenter trial in a Chinese population used 9\u2010month in\u2010segment late lumen loss (LLL) as the primary endpoint. Secondary endpoints included the 24\u2010month clinical event rates. Results: Both treatment groups were similar in terms of patient, lesion, or procedural characteristics. After the 12\u2010month follow\u2010up evaluation, additional clinical events only occurred in the PES study group. The combined rate of all\u2010cause mortality and myocardial infarction (MI) in the PCB group was significantly lower than that in the PES group (3.7% vs. 11.8%, <jats:italic>P<\/jats:italic> = 0.03). Additional subgroup analyses of 9\u2010month in\u2010segment LLL and 2\u2010year target lesion failure in patients with diabetes, small vessels, diffuse ISR, and stent margin restenosis did not show more favorable results for one specific treatment group. Conclusions: The 2\u2010year follow\u2010up demonstrated sustained long\u2010term clinical efficacy for both devices. PCB angioplasty was associated with significantly lower overall and cardiovascular mortality\/MI rates in patients with DES\u2010ISR lesions while avoiding the use of additional metal layers for drug release (ClinicalTrials.gov identifier: NCT 01622075). \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26401","type":"journal-article","created":{"date-parts":[[2016,1,17]],"date-time":"2016-01-17T08:42:45Z","timestamp":1453020165000},"page":"624-629","source":"Crossref","is-referenced-by-count":27,"title":["Two\u2010year results and subgroup analyses of the P<scp>EPCAD<\/scp> China in\u2010stent restenosis trial: A prospective, multicenter, randomized trial for the treatment of drug\u2010eluting stent in\u2010stent restenosis"],"prefix":"10.1002","volume":"87","author":[{"given":"Bo","family":"Xu","sequence":"first","affiliation":[{"name":"Fu Wai Hospital National Center for Cardiovascular Diseases Beijing 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