{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:26:46Z","timestamp":1761766006801},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"ADAPT-DES was sponsored by CRF with research support from Boston Scientific, Abbott Vascular, Medtronic, Cordis, Biosensors, The Medicines Company, Daiichi Sankyo, Eli Lilly, Volcano, and Accumetrics"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to identify angiographic predictors of 2\u2010year stent thrombosis (ST) in the ADAPT\u2010DES study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>A strong relationship between platelet reactivity and ST after implantation of drug\u2010eluting stents (DES) was recently confirmed in the prospective, multicenter ADAPT\u2010DES study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a pre\u2010specified analysis of patients enrolled in ADAPT\u2010DES, an independent angiographic core laboratory performed detailed angiographic analyses for all cases of ST. Patients with Academic Research Consortium definite\/probable target\u2010lesion ST were matched with controls in a 1:2 ratio, and multivariable Cox regression models identified angiographic predictors of 2\u2010year ST.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 8,582 patients who had successful percutaneous coronary intervention (PCI) and were included in the ADAPT\u2010DES study, 92 (1.1%) patients had ST at 2\u2010year follow\u2010up. Target lesion\u2010related ST was identified in 77 patients (82 lesions) who were clinically matched with 153 patients (196 lesions) without ST. Patients with ST were more likely to have longer target lesions, thrombus, moderate\/severe calcification, American College of Cardiology\/American Heart Association (ACC\/AHA) type C lesions, and saphenous vein grafts. After adjustment for clinical covariates the angiographic variables that predicted ST were lesion complexity (ACC\/AHA type C lesion, adjusted HR: 1.97, 95% CI: 1.19 to 3.26, <jats:italic>P<\/jats:italic>\u2009=\u20090.01) and presence of thrombus on index PCI (HR: 2.25, 95% CI: 1.40 to 3.59, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Anatomically complex lesions and the presence of thrombus are strong predictors of 2\u2010year ST in the DES era. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26409","type":"journal-article","created":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T07:00:59Z","timestamp":1453878059000},"page":"26-35","source":"Crossref","is-referenced-by-count":13,"title":["Angiographic predictors of 2\u2010year stent thrombosis in patients receiving drug\u2010eluting stents: Insights from the <scp>ADAPT\u2010DES<\/scp> 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Research Foundation New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rupa","family":"Parvataneni","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sorin J.","family":"Brener","sequence":"additional","affiliation":[{"name":"New York Methodist Hospital Brooklyn New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxana","family":"Mehran","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York New York"},{"name":"Icahn School of Medicine at Mount Sinai New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay J.","family":"Kirtane","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Foundation New York New York"},{"name":"New York\u2010Presbyterian Hospital\/Columbia University Medical Center New York New 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