{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T16:25:59Z","timestamp":1792081559477,"version":"4.4.0"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,17]],"date-time":"2016-01-17T00:00:00Z","timestamp":1452988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171016 and 81530038"],"award-info":[{"award-number":["31171016 and 81530038"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fractional flow reserve (FFR)\u2010guided revascularization strategy is popular in coronary intervention. However, the feasibility of assessing stenotic severity in intracranial large arteries using pressure gradient measurements still remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Between March 2013 and May 2014, 12 consecutive patients with intracranial large artery stenosis (including intracranial internal carotid artery, middle cerebral M1 segment, intracranial vertebral artery, and basilar artery) were enrolled in this study. The trans\u2010stenotic pressure gradient was measured before and\/or after percutaneous transluminal angioplasty and stenting (PTAS), and was then compared with percent diameter stenosis. A <jats:italic>P<\/jats:italic><jats:sub>d<\/jats:sub>\/<jats:italic>P<\/jats:italic><jats:sub>a<\/jats:sub> cut\u2010off of \u22640.70 was used to guide stenting of hemodynamically significant stenoses. The device\u2010related and procedure\u2010related serious adverse events and recurrent cerebral ischemic events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The target vessel could be reached in all cases. No technical complications occurred due to the specific study protocol. Excellent pressure signals were obtained in all patients. For seven patients who performed PTAS, the mean pre\u2010procedural pressure gradient decreased from 59.0\u2009\u00b1\u200917.2 to 13.3\u2009\u00b1\u200913.6 mm Hg after the procedure (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Only one patient who refused stenting experienced a TIA event in the ipsilateral MCA territory. No recurrent ischemic event was observed in other patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Mean trans\u2010stenotic pressure gradients can be safely and easily measured with a 0.014\u2010inch fluid\u2010filled guide wire in intracranial large arteries. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26414","type":"journal-article","created":{"date-parts":[[2016,1,17]],"date-time":"2016-01-17T08:44:37Z","timestamp":1453020277000},"page":"255-261","source":"Crossref","is-referenced-by-count":35,"title":["Severity assessment of intracranial large artery stenosis by pressure gradient measurements: A feasibility study"],"prefix":"10.1002","volume":"88","author":[{"given":"Yun\u2010Fei","family":"Han","sequence":"first","affiliation":[{"name":"Department of Neurology Jinling Hospital, Southern Medical University Nanjing 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