{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T17:38:00Z","timestamp":1700501880806},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T00:00:00Z","timestamp":1453766400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate a new transapical system which utilizes a novel designed positioning element and a two\u2010step positioning mechanism for easy and accurate implantation of transcatheter valves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve implantation is an important treatment option for non\u2010surgical patients with severe aortic stenosis. However, accurate placement of the transcatheter valve remains challenging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Self\u2010expandable aortic valve prosthesis with a flexibly connected, annulus\u2010like positioning element was implanted through a transapical approach in 12 pigs. The positioning element was separated and can be released independent of the valve prosthesis. During valve implantation, firstly, the positioning element was unsheathed and fixed into the aortic sinus. Then, the prosthetic valve was guided to an anatomically oriented position and deployed. Six animals were followed up to 180\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>With the help of the positioning element, all 12 valves were successfully deployed at the anticipated site. The valve release procedure took an average of 7.3\u00a0\u00b1\u00a02.5\u00a0min. The mean transvalvular pressure gradient was 2.8\u00a0\u00b1\u00a01.1\u00a0mm\u00a0Hg at valve deployment. Of the six chronic animals, the mean transvalvular pressure gradient was 3.0\u00a0\u00b1\u00a01.0\u00a0mm\u00a0Hg on day 7, and 2.9\u00a0\u00b1\u00a01.6\u00a0mm\u00a0Hg on day 180 (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.91). No migration, embolization, or coronary obstruction was observed during surgery and at necropsy. Pathological examination showed anatomically correct positioning of the prosthetic valve without signs of thrombosis or calcification.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, we confirmed the feasibility of the J\u2010Valve transapical system for transapical implantation through a two\u2010step process. Satisfactory hemodynamic and pathological performance during a follow\u2010up of 180\u00a0days was demonstrated. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26429","type":"journal-article","created":{"date-parts":[[2016,1,26]],"date-time":"2016-01-26T07:14:52Z","timestamp":1453792492000},"source":"Crossref","is-referenced-by-count":7,"title":["Transapical implantation of a self\u2010expandable aortic valve prosthesis utilizing a novel designed positioning element"],"prefix":"10.1002","volume":"89","author":[{"given":"Xiaopeng","family":"Liu","sequence":"first","affiliation":[{"name":"Center of Cardiac Surgery for Adults, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 People's Republic of China"},{"name":"Animal experimental center &amp; Beijing Key Laboratory of Pre\u2010clinical Research and Evaluation for Cardiovascular Implant Materials, State Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Tang","sequence":"additional","affiliation":[{"name":"Center of Cardiac Surgery for Adults, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 People's Republic of China"},{"name":"Animal experimental center &amp; Beijing Key Laboratory of Pre\u2010clinical Research and Evaluation for Cardiovascular Implant Materials, State Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuliang","family":"Luo","sequence":"additional","affiliation":[{"name":"Animal experimental center &amp; Beijing Key Laboratory of Pre\u2010clinical Research and Evaluation for Cardiovascular Implant Materials, State Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Tian","sequence":"additional","affiliation":[{"name":"Animal experimental center &amp; Beijing Key Laboratory of Pre\u2010clinical Research and Evaluation for Cardiovascular Implant Materials, State Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Li","sequence":"additional","affiliation":[{"name":"Center of Cardiac Surgery for Adults, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiakang","family":"Sun","sequence":"additional","affiliation":[{"name":"Animal experimental center &amp; Beijing Key Laboratory of Pre\u2010clinical Research and Evaluation for Cardiovascular Implant Materials, State Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liujun","family":"Jia","sequence":"additional","affiliation":[{"name":"Animal experimental center &amp; Beijing Key Laboratory of Pre\u2010clinical Research and Evaluation for Cardiovascular Implant Materials, State Key Laboratory of Cardiovascular Disease Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Center of Cardiac Surgery for Adults, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,1,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.907402"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht381"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2011.164"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.946533"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV8I5A94"},{"key":"e_1_2_7_8_1","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1016\/j.ejcts.2011.01.078","article-title":"Trans\u2010apical aortic valve implantation using a new self\u2010expandable bioprosthesis: initial outcomes","volume":"40","author":"Kempfert J","year":"2011","journal-title":"Eur J Cardiothorac Surg"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs389"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezs129"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.217158"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.048"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.22093"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehq445"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.01.138"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2013.11.035"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.26429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.26429","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.26429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T19:59:29Z","timestamp":1695758369000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.26429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,1,26]]},"references-count":16,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017,1]]}},"alternative-id":["10.1002\/ccd.26429"],"URL":"https:\/\/doi.org\/10.1002\/ccd.26429","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,1,26]]}}}