{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T07:10:48Z","timestamp":1695798648935},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,2,23]],"date-time":"2016-02-23T00:00:00Z","timestamp":1456185600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of our study was to study the impact of glycoprotein IIb\/IIIa inhibitors (GPI) on in\u2010hospital outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>There is paucity of data regarding the impact of GPI on the outcomes following peripheral endovascular interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study cohort was derived from Healthcare Cost and Utilization Project (HCUP) Nationwide Inpatient Sample (NIS) database between the years 2006 and 2011. Peripheral endovascular interventions and GPI utilization were identified using appropriate ICD\u20109 Diagnostic and procedural codes. Two\u2010level hierarchical multivariate mixed models were created. The study outcomes were: primary (in\u2010hospital mortality and amputation studied separately) and secondary (composite of in\u2010hospital mortality and postprocedural complications). Hospitalization costs were also assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>GPI utilization (OR, 95% CI, <jats:italic>P<\/jats:italic>\u2010value) was independently predictive of lower amputation rates (0.36, 0.27\u20130.49, &lt;0.001). There was no significant difference in terms of in\u2010hospital mortality (0.59, 0.31\u20131.14, <jats:italic>P<\/jats:italic> 0.117), although GPI use predicted worse secondary outcomes (1.23, 1.03\u20131.47, 0.023). Following propensity matching, the amputation rate was lower (3.2% vs. 8%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), while hospitalization costs were higher in the cohort that received GPI ($21,091\u2009\u00b1\u2009404 vs. 19,407\u2009\u00b1\u2009133, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Multivariate analysis revealed GPI use in peripheral endovascular interventions to be suggestive of an increase in composite end\u2010point of in\u2010hospital mortality and postprocedural complications, no impact on in\u2010hospital mortality alone, significantly lower rate of amputation, and increase in hospitalization costs. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26452","type":"journal-article","created":{"date-parts":[[2016,2,25]],"date-time":"2016-02-25T17:43:06Z","timestamp":1456422186000},"page":"605-616","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Glycoprotein IIb\/IIIa Inhibitors Use on Outcomes After Lower Extremity Endovascular Interventions From Nationwide Inpatient Sample (2006\u20132011)"],"prefix":"10.1002","volume":"88","author":[{"given":"Shilpkumar","family":"Arora","sequence":"first","affiliation":[{"name":"Mount Sinai St. Luke's Roosevelt Hospital New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidakpal S.","family":"Panaich","sequence":"additional","affiliation":[{"name":"Borgess Medical Center Kalamazoo Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nilay","family":"Patel","sequence":"additional","affiliation":[{"name":"Saint Peter's University Hospital New Brunswick New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nileshkumar J.","family":"Patel","sequence":"additional","affiliation":[{"name":"University of Miami Miller School of Medicine Miami Florida"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sopan","family":"Lahewala","sequence":"additional","affiliation":[{"name":"Jersey City Medical Center Jersey City New Jersey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Badal","family":"Thakkar","sequence":"additional","affiliation":[{"name":"Tulane School of Public Health &amp; 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