{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T05:59:05Z","timestamp":1774418345930,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,2,19]],"date-time":"2016-02-19T00:00:00Z","timestamp":1455840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the impact of baseline left ventricular (LV) function on the clinical outcomes of patients with functional mitral regurgitation (FMR) treated with MitraClip.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>It is unknown whether patients with significant FMR and severe LV dysfunction benefit from MitraClip.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 77 patients with significant FMR undergoing MitraClip procedure between December 2010 and January 2015 was categorized by baseline LV ejection fraction (LVEF) into tertiles: LVEF &lt;27% (<jats:italic>n<\/jats:italic>\u2009=\u200927), LVEF 27\u201337% (<jats:italic>n<\/jats:italic>\u2009=\u200925), and LVEF &gt;37% (<jats:italic>n<\/jats:italic>\u2009=\u200925). We sought to evaluate the impact of LVEF on all\u2010cause mortality at follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no significant differences in baseline comorbidities, medical treatment and MR severity among tertiles of LVEF. Overall procedural success was 94%, with no differences among groups (LVEF &lt;27%: 89%; LVEF 27\u201337%: 100%; LVEF &gt;37%: 92%; <jats:italic>P<\/jats:italic>\u2009=\u20090.25). Median follow\u2010up was 372 days (interquartile range: 128\u2013627 days). MR severity improved in all three groups, as compared to baseline. There were no differences in the prevalence of MR \u22642+ on follow\u2010up (<jats:italic>P<\/jats:italic>\u2009=\u20090.40). Mortality was highest in patients with LVEF &lt;27% (41%), as compared with LVEF 27\u201337% (16%) and LVEF &gt;37% (4%), <jats:italic>P<\/jats:italic>\u2009=\u20090.004. Patient who died had a lower baseline LVEF compared to those who survived (24.8\u2009\u00b1\u20097.7% versus 35.5\u2009\u00b1\u200913.7%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). An LVEF &lt;27% was an independent predictor of mortality after adjusting for procedural success: hazard ratio 3.4 (95% CI: 1.1 to 10.0; <jats:italic>P<\/jats:italic>\u2009=\u20090.030).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MitraClip is effective in FMR patients regardless of the severity of LV dysfunction. However, low baseline LVEF is associated with increased mortality, despite procedural success. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26460","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T13:43:07Z","timestamp":1455975787000},"page":"1124-1133","source":"Crossref","is-referenced-by-count":11,"title":["Impact of left ventricular function on clinical outcomes of functional mitral regurgitation patients undergoing transcatheter mitral valve repair"],"prefix":"10.1002","volume":"88","author":[{"given":"Lorenzo","family":"Azzalini","sequence":"first","affiliation":[{"name":"Department of Medicine, Interventional Cardiology and Echocardiography Montreal Heart Institute, Universit\u00e9 De Montr\u00e9al Montr\u00e9al Qubec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xavier","family":"Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Department of Medicine, Interventional Cardiology and Echocardiography Montreal Heart Institute, Universit\u00e9 De Montr\u00e9al Montr\u00e9al Qubec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Razi","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Interventional Cardiology and Echocardiography Montreal Heart Institute, Universit\u00e9 De Montr\u00e9al Montr\u00e9al Qubec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Couture","sequence":"additional","affiliation":[{"name":"Department of Medicine, Interventional Cardiology and Echocardiography Montreal Heart Institute, Universit\u00e9 De Montr\u00e9al Montr\u00e9al Qubec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anique","family":"Ducharme","sequence":"additional","affiliation":[{"name":"Department of Medicine, Interventional Cardiology and Echocardiography Montreal Heart Institute, Universit\u00e9 De Montr\u00e9al Montr\u00e9al Qubec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ars\u00e8ne","family":"Basmadjian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Interventional Cardiology and Echocardiography Montreal Heart Institute, Universit\u00e9 De Montr\u00e9al Montr\u00e9al Qubec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoul","family":"Bonan","sequence":"additional","affiliation":[{"name":"Department of Medicine, Interventional Cardiology and Echocardiography Montreal Heart Institute, Universit\u00e9 De Montr\u00e9al Montr\u00e9al Qubec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anita W.","family":"Asgar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Interventional Cardiology and Echocardiography Montreal Heart Institute, Universit\u00e9 De Montr\u00e9al Montr\u00e9al Qubec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,2,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2011.225789"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0828-282X(07)70830-9"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfp051"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009355"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.02.094"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0894-7317(03)00335-3"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq030"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV9I1A13"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1166"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2011.09.033"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25715"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.02.009"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1755-5922.12058"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr029"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.06.061"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2014.03.015"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I6A128"},{"key":"e_1_2_6_20_1","doi-asserted-by":"crossref","unstructured":"PighiM Estevez\u2010LoureiroR MaisanoF UssiaGP Dall'AraG FranzenO WinterR NickenigG GilardM DiMarioC.TCT\u201058 Immediate and long\u2010term outcomes of ischemic versus non\u2010ischemic functional mitral regurgitation in patients treated with MitraClip: insights from the 2011\u201312 Pilot European Sentinel Registry of Percutaneous Edge\u2010to\u2010Edge Mitral Valve Repair. Presented at Transcatheter Cardiovascular Therapeutics Congress 2015. San Francisco October 11\u201315 2015.","DOI":"10.1016\/j.jacc.2015.08.107"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu114"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2012-303105"}],"container-title":["Catheterization and Cardiovascular Interventions"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.26460","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fccd.26460","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ccd.26460","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,7]],"date-time":"2023-10-07T03:49:35Z","timestamp":1696650575000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ccd.26460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,2,19]]},"references-count":21,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2016,12]]}},"alternative-id":["10.1002\/ccd.26460"],"URL":"https:\/\/doi.org\/10.1002\/ccd.26460","archive":["Portico"],"relation":{},"ISSN":["1522-1946","1522-726X"],"issn-type":[{"value":"1522-1946","type":"print"},{"value":"1522-726X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,2,19]]}}}