{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T22:32:20Z","timestamp":1761863540606},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The purpose of the present study was to investigate whether transfemoral implantation of the balloon\u2010expandable Edwards SAPIEN 3 device without prior balloon valvuloplasty is feasible.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve implantation (TAVI) without predilatation may be advantageous and is feasible with various transcatheter heart valves.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 163 consecutive patients with severe aortic stenosis undergoing transfemoral TAVI were enrolled at two sites. We assessed whether the crossing of the native aortic valve with the prosthesis without prior pre\u2010dilation was feasible and evaluated for procedural success according to VARC\u20102 criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Direct implantation without pre\u2010dilatation was feasible in 154 patients (94.5%), whereas in nine patients predilatation was required due to difficulties while crossing the native aortic valve. Procedural success was achieved in 85.6%. A large proportion of the procedural failures was mainly driven by increased post\u2010procedural gradients \u226520 mm Hg, which almost exclusively concerned the smaller prostheses sizes (23\u2010mm 10\/39 (25.6%) vs. 26\u2010mm 5\/72 (6.9%) vs. 29\u2010mm 1\/52 (1.9%); <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Patients in the pre\u2010ballooning group had higher calcium scores of the aortic valve (5,335 [4,421\u20137,807] vs. 2,893 [1,879\u20133,993]), more advanced age, higher transvalvular gradients, and smaller aortic valve area.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The transfemoral implantation of the balloon\u2010expandable SAPIEN 3 prosthesis without pre\u2010dilatation is feasible in the majority of cases. In the presence of severe aortic valve calcification and critical aortic stenosis, however, predilatation may still be necessary. Furthermore, the significance of increased post\u2010procedural gradients requires further verification. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26464","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T07:45:27Z","timestamp":1457250327000},"source":"Crossref","is-referenced-by-count":18,"title":["Transfemoral aortic valve implantation of Edwards SAPIEN 3 without predilatation"],"prefix":"10.1002","volume":"89","author":[{"given":"Won\u2010Keun","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Cardiology Kerckhoff Heart Center Bad Nauheim Germany"},{"name":"Department of Cardiac Surgery Kerckhoff Heart Center Bad Nauheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabien","family":"Praz","sequence":"additional","affiliation":[{"name":"Department of Cardiology Bern University Hospital Bern 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