{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T10:32:21Z","timestamp":1772620341064,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T00:00:00Z","timestamp":1457308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To compare second generation drug eluting stents (2DES) with first generation (1DES) for the treatment of patients (pts) with multiple coronary vessel disease (MVD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Although 2DES improved safety and efficacy compared to 1DES, MVD remains a challenge for percutaneous coronary interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>ERACI IV was a prospective, observational, and controlled study in pts with MVD including left main and treated with 2DES (Firebird 2, Microport). We included 225 pts in 15 sites from Argentina. Primary endpoint was the incidence of major adverse cardiovascular events (MACCE) defined as death, myocardial infarction (MI), cerebrovascular accident (CVA) and unplanned revascularization; and to compare with 225 pts from ERACI III study (1DES). PCI strategy was planned to treat lesions \u226570% in vessels\u2009\u2265\u20092.00 mm, introducing a modified Syntax score (SS) where severe lesions in vessels\u2009&lt;\u20092.0 mm and intermediate lesions were not scored.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Baseline characteristics showed that compared to ERACI III, ERACI IV pts had higher number of diabetics (<jats:italic>P<\/jats:italic>\u2009=\u20090.02), previous revascularization (<jats:italic>P<\/jats:italic>\u2009=\u20090.007), unstable angina IIb\/IIIc (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and three vessels\/left main disease (<jats:italic>P<\/jats:italic>\u2009=\u20090.003). Modified SS was 22.2\u2009\u00b1\u200911. At 2 years of follow\u2010up ERACI IV group had significantly lower incidence of death+ MI\u2009+\u2009CVA, (<jats:italic>P<\/jats:italic>\u2009=\u20090.01) and MACCE (<jats:italic>P<\/jats:italic>\u2009=\u20090.001). MACCE rate was similar in diabetics, (5.8%) and nondiabetics (7.0%). After performing a matched propensity score, MACCE remain significantly lower in ERACI IV (<jats:italic>P<\/jats:italic>\u2009=\u20090.005).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This registry showed that 2DES in MVD has a remarkable low incidence of MACCE in unadjusted and adjusted analysis. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26468","type":"journal-article","created":{"date-parts":[[2016,3,7]],"date-time":"2016-03-07T08:58:42Z","timestamp":1457341122000},"page":"37-46","source":"Crossref","is-referenced-by-count":15,"title":["Second vs. First generation drug eluting stents in multiple vessel disease and left main stenosis: Two\u2010year follow\u2010up of the observational, prospective, controlled, and multicenter ERACI IV registry"],"prefix":"10.1002","volume":"89","author":[{"given":"Carlos","family":"Haiek","sequence":"first","affiliation":[{"name":"Interventional Cardiology Department Sanatorio De La Trinidad Quilmes Buenos Aires Province Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Fern\u00e1ndez\u2010Pereira","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department Clinica IMA Adrogu\u00e9 Buenos Aires Province Argentina"},{"name":"Clinical Research Department Centro De Estudios En Cardiolog\u00eda Intervencionista Buenos Aires City Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Omar","family":"Santaera","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department Cl\u00ednica Privada Provincial Merlo Buenos Aires Province Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Mieres","sequence":"additional","affiliation":[{"name":"Clinical Research Department Centro De Estudios En Cardiolog\u00eda Intervencionista Buenos Aires City Argentina"},{"name":"Interventional Department Sanatorio Las Lomas San Isidro Buenos Aires Province Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Rifourcat","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department Instituto De Diagn\u00f3stico Y Tratamiento De Afecciones Cardiovasculares La Plata Buenos Aires Province Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Lloberas","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department Sanatorio San Miguel, San Miguel Buenos Aires Province Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Larribau","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department Hospital Espa\u00f1ol Godoy Cruz City Mendoza Province Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Pocov\u00ed","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department Centro Medico Talar San Isidro Buenos Aires Province Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo M.","family":"Rodriguez\u2010Granillo","sequence":"additional","affiliation":[{"name":"Clinical Research Department Centro De Estudios En Cardiolog\u00eda Intervencionista Buenos Aires City Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo A.","family":"Sarmiento","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department Hospital El Cruce Florencio Varela Buenos Aires Province Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Antoniucci","sequence":"additional","affiliation":[{"name":"Cardiology Department Careggi Hospital Firenze Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfredo E.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Clinical Research Department Centro De Estudios En Cardiolog\u00eda Intervencionista Buenos Aires City Argentina"},{"name":"Cardiology Department Sanatorio Otamendi Y Miroli Buenos Aires City Argentina"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804626"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211585"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.10.014"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60141-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.06.1182"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.07.106"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.803528"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr479"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2013.10.006"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2013.07.012"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.05.038"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV9I4A74"},{"key":"e_1_2_6_14_1","first-page":"0019","article-title":"Revascularization 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