{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T23:00:55Z","timestamp":1762210855666},"reference-count":36,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,4]],"date-time":"2016-03-04T00:00:00Z","timestamp":1457049600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Drug eluting stents (DES) are associated with reduced risk of restenosis when compared with bare metal stents (BMS). Their use in ST\u2010elevation myocardial infarction (STEMI) is debated, owing to concerns about stent thrombosis. There are limited real\u2010world data comparing DES versus BMS in STEMI. We conducted an observational analysis in this setting and rigorously adjusted for treatment selection bias.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed 11,181 consecutive patients with acute STEMI who received either DES or BMS during 2008\u20102014 in the British Columbia Cardiac Registry. We analyzed target vessel revascularization (TVR) and mortality at 2\u00a0years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multivariable\u2010adjusted, propensity\u2010matched and inverse probability\u2010treatment weighted analyses found DES to be associated with early and late survival up to 2\u00a0years but not TVR. However, when adjusting for measured and unmeasured confounders, instrumental variable (IV) analyses demonstrated that DES use was associated with reduced TVR up to 2\u00a0years (\u0394\u2009=\u2009\u22126.7%, 95% CI: \u221210.0%, \u22123.4%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). DES use was not associated with mortality at 1\u00a0year (\u0394\u2009=\u2009\u22122.3%, 95% CI: \u22125.0%, 0.4%, <jats:italic>P<\/jats:italic>\u2009=\u20090.100) but associated with reduced mortality at 2\u00a0years (\u0394\u2009=\u2009\u22125.4%, 95% CI: \u22128.3%, \u22122.5%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Stratified IV analyses indicated that this long\u2010term survival benefit was largely attributable to the second generation DES.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study of patients with STEMI, when adjusting for measured and unmeasured factors, DES use was associated with reduced TVR and long\u2010term survival beyond 1\u00a0year. This long\u2010term survival was largely attributable to the second generation DES. These real\u2010world data are reassuring and support the use of DES for STEMI. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26479","type":"journal-article","created":{"date-parts":[[2016,3,6]],"date-time":"2016-03-06T02:46:54Z","timestamp":1457232414000},"page":"24-35","source":"Crossref","is-referenced-by-count":11,"title":["Long\u2010term outcomes following drug\u2010eluting stents versus bare metal stents for primary percutaneous coronary intervention: A real\u2010world analysis of 11,181 patients from the british columbia cardiac registry"],"prefix":"10.1002","volume":"88","author":[{"given":"M. Bilal","family":"Iqbal","sequence":"first","affiliation":[{"name":"Victoria Heart Institute Foundation Victoria British Columbia Canada"},{"name":"Royal Jubilee Hospital Victoria British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imad J.","family":"Nadra","sequence":"additional","affiliation":[{"name":"Victoria Heart Institute Foundation Victoria British Columbia Canada"},{"name":"Royal Jubilee Hospital Victoria British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lillian","family":"Ding","sequence":"additional","affiliation":[{"name":"Provincial Health Services Authority Vancouver British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Fung","sequence":"additional","affiliation":[{"name":"Vancouver General Hospital Vancouver British Columbia 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Della","family":"Siega","sequence":"additional","affiliation":[{"name":"Victoria Heart Institute Foundation Victoria British Columbia Canada"},{"name":"Royal Jubilee Hospital Victoria British Columbia Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"On Behalf of the British Columbia Cardiac Registry Investigators","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)12113-7"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1161\/CIRCULATIONAHA.107.188209","article-title":"2007 focused update of the ACC\/AHA 2004 guidelines for the management of patients with ST\u2010elevation myocardial infarction: A report of the American college of cardiology\/American heart association task force on practice guidelines: developed in collaboration with 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