{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T00:46:42Z","timestamp":1785199602718,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,3,29]],"date-time":"2016-03-29T00:00:00Z","timestamp":1459209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To describe medium\u2010 to long\u2010term follow\u2010up of patients undergoing device closure of patent foramen ovale (PFO) for stroke or transient ischemic attack (TIA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter device closure of PFO continues to be used for secondary prevention of cryptogenic stroke or TIA, but data are lacking regarding long\u2010term outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the Mayo Clinic Rochester PFO database for patients who underwent device closure of PFO for secondary prevention of stroke\/TIA from December 2001 to June 2012. Demographic, clinical, procedural, and follow\u2010up data were reviewed. Recurrence rate of stroke\/TIA were calculated. Data were analyzed to identify risk factors of recurrent neurologic events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Seven hundred and thirty patients (mean age 53 years; 40% female) were included in our study. Most patients (72%) had cryptogenic stroke as their qualifying event for PFO closure. There were no procedure\u2010related deaths or strokes. The most commonly used device was the Amplatzer Septal Occluder (82%). Median follow\u2010up was 6 years. A 3.9% of patients had documented residual right\u2010to\u2010left shunting at last echocardiogram. Recurrent stroke and\/or TIA were reported in 45 patients, (6.3% of patients with follow\u2010up data). Patients who experienced recurrent stroke\/TIA were older and had a higher rate of diabetes and hypertension than those who did not. The presence of residual shunt did not correlate with risk of recurrent events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Device closure of PFO can be performed safely with very good long\u2010term resolution of atrial shunting. Recurrent neurologic events after PFO closure may reflect additional comorbid risk factors unrelated to the potential for paradoxical embolism. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26518","type":"journal-article","created":{"date-parts":[[2016,3,31]],"date-time":"2016-03-31T20:10:35Z","timestamp":1459455035000},"page":"124-133","source":"Crossref","is-referenced-by-count":21,"title":["Long\u2010term follow\u2010up after PFO device closure"],"prefix":"10.1002","volume":"89","author":[{"given":"Nathaniel W.","family":"Taggart","sequence":"first","affiliation":[{"name":"Division of Pediatric Cardiology Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy S.","family":"Reeder","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Diseases Mayo Clinic Rochester Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan 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