{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:46:01Z","timestamp":1789911961044,"version":"4.0.1"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T00:00:00Z","timestamp":1462233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Anemia is linked to impaired outcome in patients with cardiovascular diseases. We sought to characterize the impact of baseline anemia on mid\u2010term outcome after transcatheter aortic valve implantation (TAVI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Data of 1201 consecutive TAVI patients were retrospectively analyzed. Baseline anemia was defined according to the WHO (hemoglobin &lt;12g\/dl [female], &lt;13g\/dl [male]). It was prevalent in 59.0% of patients and associated with a higher preoperative risk (STS\u2010PROM 7.8\u2009\u00b1\u20095.7 vs. 6.2\u2009\u00b1\u20094.1%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Survival was similar at 30 days (90.5 vs. 91.2%, <jats:italic>P<\/jats:italic>\u2009=\u20090.626) but NYHA functional capacity was impaired in patients with baseline anemia (classes III\/IV: 20.6 vs. 15.6%, <jats:italic>P<\/jats:italic>\u2009=\u20090.006). Low baseline hemoglobin (OR 0.85, CI 0.73\u20130.98, <jats:italic>P<\/jats:italic>\u2009=\u20090.025), blood transfusion (OR 2.42, CI 1.38\u20134.28, <jats:italic>P<\/jats:italic>\u2009=\u20090.002), and bleeding complications (OR 2.21, CI 1.27\u20103.81, <jats:italic>P<\/jats:italic>\u2009=\u20090.005) were in addition associated with acute kidney injury after TAVI. Three\u2010year survival was reduced (49.6 vs. 64.9%, <jats:italic>P<\/jats:italic>\u2009=\u20090.002) and baseline anemia was linked to increased mid\u2010term mortality (HR 1.43, CI 1.13\u20131.82, <jats:italic>P<\/jats:italic>\u2009=\u20090.003), however its effect was surpassed by the adverse impact of periprocedural complications. <jats:italic>Conclusions<\/jats:italic>: Baseline anemia was associated with increased morbidity and mortality after TAVI. Preprocedural hemoglobin levels need to be assessed for risk stratification and blood conservation management seems essential. As a potentially modifiable target, the role of pretreatment of anemia prior to TAVI remains to be determined. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26563","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T14:00:16Z","timestamp":1462370416000},"source":"Crossref","is-referenced-by-count":18,"title":["Baseline anemia and its impact on midterm outcome after transcatheter aortic valve implantation"],"prefix":"10.1002","volume":"89","author":[{"given":"Moritz","family":"Seiffert","sequence":"first","affiliation":[{"name":"Department of General and Interventional Cardiology University Heart Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lenard","family":"Conradi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery University Heart Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Gutwein","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology University Heart Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Sch\u00f6n","sequence":"additional","affiliation":[{"name":"Department of Medical Biometry and Epidemiology University Medical Center Hamburg\u2010Eppendorf Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Deuschl","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology University Heart Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niklas","family":"Schofer","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology University Heart Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"Becker","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology University Heart Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Schirmer","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery University Heart Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Reichenspurner","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery University Heart Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Blankenberg","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology University Heart Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik","family":"Treede","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery University Heart Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Sch\u00e4fer","sequence":"additional","affiliation":[{"name":"Department of General and Interventional Cardiology University Heart Center Hamburg Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs109"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052622.51963.FC"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2012.10.024"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.04.047"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.04.042"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.09.019"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezt143"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2013.06.030"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.292.13.1555"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/2013.jamainternmed.1001"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.12.073"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2014.980"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.698977"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25691"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.113.000409"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV7I2A32"},{"key":"e_1_2_6_18_1","unstructured":"World Health Organisation. 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