{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:31:45Z","timestamp":1780554705868,"version":"3.54.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,3]],"date-time":"2016-05-03T00:00:00Z","timestamp":1462233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Surgical aortic bioprosthetic valves deteriorate 10 to 20 years after operation. Valve\u2010in\u2010valve implantation with first generation transcatheter aortic valve implantation (TAVI) devices has shown to be feasible. We report a first case series with the new Edwards Sapien 3 valve for transfemoral aortic valve\u2010in\u2010valve implantation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and results<\/jats:title><jats:p>Nine patients underwent valve\u2010in\u2010valve\u2010TAVI with the Edward Sapien 3 valve. Seven patients presented with severe aortic stenosis and two patients with severe aortic insufficiency of surgical aortic bioprosthesis. Procedures were performed in local anaesthesia under fluoroscopic guidance with pre\u2010procedural 256 multislice computed tomography for procedural planning. In all patients the Edwards Sapien 3 was successfully implanted decreasing the mean echocardiographic gradient from 42\u2009\u00b1\u200922mmHg to 18\u2009\u00b1\u20097mmHg (p\u2009&lt;\u20090.01). Device success according to VARC 2 criteria was achieved in 8 out of 9 patients. There was no death, coronary obstruction, use of second valve or need for post\u2010dilation. Furthermore there were no access\u2010site complications, no minor or major bleedings or vascular injury. Two patients required pacemaker implantation within the first 7 days after valve\u2010in\u2010valve TAVI. Post\u2010procedural echocardiography demonstrated no or trace aortic regurgitation. Early safety events within 30 days according to VARC\u20102 definition occurred in 1 patient.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The Edwards Sapien 3 valve for treatment of failed surgical bioprostheses is feasible and is associated with no relevant post\u2010procedural aortic regurgitation and a low risk of access site complications. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26565","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T13:52:18Z","timestamp":1462369938000},"page":"636-643","source":"Crossref","is-referenced-by-count":9,"title":["Transfemoral valve\u2010in\u2010valve implantation for degenerated bioprosthetic aortic valves using the new balloon\u2010expandable Edwards Sapien 3 valve"],"prefix":"10.1002","volume":"88","author":[{"given":"Birgid","family":"Gonska","sequence":"first","affiliation":[{"name":"Department Of Internal Medicine II University of Ulm Ulm 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