{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T09:12:55Z","timestamp":1771233175311,"version":"3.50.1"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,2,15]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We sought to examine whether baseline diastolic dysfunction (DD) is associated with increased mortality in patients who develop aortic insufficiency (AI) after transcatheter aortic valve replacement (TAVR). Background: Significant post\u2010TAVR AI is associated with increased mortality, likely secondary to adverse hemodynamics secondary to volume overload and decreased LV compliance from chronic pressure overload. However, the effect of baseline DD on outcomes of patients with post\u2010TAVR AI has not been studied. Methods: A total of 195 patients undergoing TAVR were included in the study. Patients with moderate\u2010to\u2010severe mitral stenosis, prior mitral valve replacement or atrial fibrillation were excluded. DD was classified at baseline by a 2\u2010step approach as recommended by the American Society of Echocardiography while AI was evaluated 30 days post\u2010TAVR. Follow up data up to 2 years post\u2010TAVR was used in survival analysis. Results: Patients with severe baseline DD who developed \u2265mild post\u2010TAVR AI had increased mortality compared to all other patients (HR\u2009=\u20093.89, CI: 1.76\u20138.6, <jats:italic>P<\/jats:italic>\u2009=\u20090.001), which remained significant after adjusting for post\u2010TAVR AI, pre\u2010TAVR AI, baseline mitral regurgitation, ejection fraction, pulmonary artery pressure, creatinine clearance and history of stroke. Conclusions: Even mild post\u2010TAVR AI may have a negative impact on outcomes of patients with underlying severe DD. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26582","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T23:41:20Z","timestamp":1464133280000},"page":"445-451","source":"Crossref","is-referenced-by-count":8,"title":["Prognostic Importance of Diastolic Dysfunction in Relation to Post Procedural Aortic Insufficiency in Patients Undergoing Transcatheter Aortic Valve Replacement"],"prefix":"10.1002","volume":"89","author":[{"given":"Polydoros N.","family":"Kampaktsis","sequence":"first","affiliation":[{"name":"William Acquavella Heart Valve Center, New York Presbyterian Hospital \/ Weill Cornell Medical College New York New York"},{"name":"Department of Internal Medicine New York Presbyterian Hospital \/ Weill Cornell Medical College New York New 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