{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T02:20:48Z","timestamp":1771899648314,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T00:00:00Z","timestamp":1464048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Epicardial focal coronary artery stenosis, diffuse coronary disease, and microvascular resistance (MR) may limit coronary flow. The purpose of percutaneous coronary intervention (PCI) is to increase coronary flow by targeting epicardial lesions. After PCI, MR might change and affect coronary flow. We investigated whether PCI influences MR using the index of microcirculatory resistance (IMR) and if pre\u2010PCI fractional flow reserve (FFR) or MR predicts the post\u2010PCI change in hyperaemic coronary flow.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>This prospective study included 245 vessels from 229 patients with stable angina pectoris undergoing elective PCI. FFR and IMR were measured before and after PCI. Post\u2010PCI increase in hyperaemic coronary flow was assessed using the change in thermodilution\u2010derived transit time (pre\u2010PCI <jats:italic>T<\/jats:italic><jats:sub>mn<\/jats:sub> \u2013 post\u2010PCI <jats:italic>T<\/jats:italic><jats:sub>mn<\/jats:sub>). IMR significantly decreased after PCI (median 1.9; interquartile range, \u22124.9 to 10.1) and was significantly associated with pre\u2010PCI IMR (<jats:italic>r<\/jats:italic>\u2009=\u20090.70, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). Increased coronary flow was significantly correlated with pre\u2010PCI IMR (<jats:italic>r<\/jats:italic>\u2009=\u20090.62, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and pre\u2010PCI FFR (<jats:italic>r<\/jats:italic>\u2009=\u20090.51, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001). In multivariate analysis, factors significantly associated with decreased post\u2010PCI IMR were pre\u2010PCI IMR (odds ratio [OR], 1.13; 95% confidence interval [CI], 1.08\u20131.19; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and angiographic reference diameter (OR, 2.44; 95% CI; 1.09\u20135.48; <jats:italic>P<\/jats:italic>\u2009=\u20090.03). Factors significantly associated with increased coronary flow post\u2010PCI were pre\u2010PCI IMR (OR, 1.15; 95% CI, 1.08\u20131.23; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001) and pre\u2010PCI FFR (OR, &lt;0.001; 95% CI, 0.000\u20130.003; <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PCI affected MR. Pre\u2010PCI FFR and MR were independent predictors of post\u2010PCI changes in hyperaemic coronary flow. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26596","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T23:44:53Z","timestamp":1464133493000},"page":"233-242","source":"Crossref","is-referenced-by-count":21,"title":["Preprocedural fractional flow reserve and microvascular resistance predict increased hyperaemic coronary flow after elective percutaneous coronary intervention"],"prefix":"10.1002","volume":"89","author":[{"given":"Tadashi","family":"Murai","sequence":"first","affiliation":[{"name":"Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihisa","family":"Kanaji","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taishi","family":"Yonetsu","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsumin","family":"Lee","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junji","family":"Matsuda","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisuke","family":"Usui","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Araki","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Niida","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuaki","family":"Isobe","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine Tokyo Medical and Dental University Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsunekazu","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Tsuchiura Kyodo General Hospital Tsuchiura Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.082"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra061889"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.109.900191"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2010.01.054"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000151610.98409.2F"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.001942"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.111.966556"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-305124"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000128669.99355.CB"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000080700.98607.D1"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/hc4201.099223"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000017199.09457.3D"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000143893.18451.0E"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.01021.2002"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.105.587196"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.001345"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.113.001049"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV5I8A158"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.112.972224"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.66.2.503"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.54.6.760"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2013.86"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000112571.06979.B2"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.111.964718"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.114.001715"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.07.973"}],"container-title":["Catheterization 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