{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T05:39:09Z","timestamp":1784007549609,"version":"3.55.0"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T00:00:00Z","timestamp":1470960000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To evaluate the long\u2010term prognostic value of risk scores in the setting of drug\u2010eluting stent (DES) implantation for uLMCA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Data on the prognostic value of novel risk scores developed to select the most appropriate revascularization strategy in patients undergoing DES implantation for uLMCA disease are relatively limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study represents a patient\u2010level pooled analysis of the ISAR\u2010LEFT\u2010MAIN (607 patients randomized to paclitaxel\u2010eluting or sirolimus\u2010eluting stents) and the ISAR\u2010LEFT\u2010MAIN\u20102 (650 patients randomized to everolimus\u2010eluting or zotarolimus\u2010eluting stents) randomized trials. The Syntax Score (SxScore) as well the Syntax Score II (SS\u2010II), the EuroSCORE and the Global Risk Classification (GRC) were calculated. The primary outcome was all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At a mean follow\u2010up of 3 years there were 160 deaths (12.7%). The death\u2010incidence was significantly higher in the upper tertiles than in the intermediate or lower ones for all risk scores (log\u2010rank test <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01 for all comparisons). The discriminatory power of a multivariable model for prediction of 3\u2010year mortality was significantly improved after the inclusion of EuroSCORE (adjusted area under the receiver operating characteristic (ROC) curve\u2009=\u20090.779, 95% confidence interval 0.747 to 0.810, <jats:italic>P<\/jats:italic>\u2009=\u20090.008), but not after the inclusion of SxScore, SS II, or GRC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In patients undergoing DES implantation for uLMCA disease, all evaluated risk scores were able to stratify the mortality risk at long\u2010term follow\u2010up. EuroSCORE was the only risk score that significantly improved the discriminatory power of a multivariable model to predict long\u2010term mortality. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26645","type":"journal-article","created":{"date-parts":[[2016,8,12]],"date-time":"2016-08-12T07:19:07Z","timestamp":1470986347000},"page":"1-10","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term prognostic value of risk scores after drug\u2010eluting stent implantation for unprotected left main coronary artery: A pooled analysis of the ISAR\u2010LEFT\u2010MAIN and ISAR\u2010LEFT\u2010MAIN 2 randomized clinical trials"],"prefix":"10.1002","volume":"89","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0728-2819","authenticated-orcid":false,"given":"Erion","family":"Xhepa","sequence":"first","affiliation":[{"name":"Deutsches Herzzentrum Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohisa","family":"Tada","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Kufner","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gjin","family":"Ndrepepa","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Kreutzer","sequence":"additional","affiliation":[{"name":"Deutsches Herzzentrum Technische Universit\u00e4t M\u00fcnchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareq","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Medizinische Klinik, Klinikum rechts der Isar Technische Universit\u00e4t Muenchen Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Tiroch","sequence":"additional","affiliation":[{"name":"Helios Clinic Wuppertal Med. 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