{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T23:13:46Z","timestamp":1782947626714,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,7,29]],"date-time":"2016-07-29T00:00:00Z","timestamp":1469750400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Sociedade Brasileira de Hemodinamica e Cardiologia Intervencionista, Sao Paulo-SP, Brazil"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,2,15]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aimed to compare gender\u2010related differences in outcomes of patients undergoing TAVI over a long\u2010term follow\u2010up period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Transcatheter aortic valve implantation (TAVI) has been considered the standard therapy for patients with inoperable or high\u2010risk symptomatic aortic stenosis. The influence of gender\u2010related differences in outcomes of patients undergoing TAVI is currently on debate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2008 to January 2015, 819 patients (49% men) underwent TAVI and were included in a multicenter Brazilian registry. Patients were followed\u2010up and clinical outcomes were evaluated according to the updated Valve Academic Research Consortium\u20102 criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean follow\u2010up was 497\u2009\u00b1\u2009478 days. Compared with women, men had a lower rate of major or life\u2010threatening bleeding (12.0% vs. 20.6%; HR\u2009=\u20090.57 [95CI% 0.40\u20130.81]; <jats:italic>P<\/jats:italic>\u2009=\u20090.001), and major vascular complications (6% vs. 11.7%; HR\u2009=\u20090.50 [95CI% 0.31\u20130.82]; <jats:italic>P<\/jats:italic>\u2009=\u20090.004). At 30 days, all\u2010cause mortality was lower in men than in women (6.5% vs. 11.5%; <jats:italic>P<\/jats:italic>\u2009=\u20090.013), however, cumulative all\u2010cause mortality was similar between groups (25.9% vs. 29.7%, men and women, respectively, HR\u2009=\u20090.92 [95CI% 0.71\u20131.19]; <jats:italic>P<\/jats:italic>\u2009=\u20090.52) over the entire follow\u2010up period. By adjusted Cox regression model, renal function, diabetes, peripheral artery disease, and chronic obstructive pulmonary disease (COPD) remained independently predictors of all\u2010cause mortality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this large\u2010scale study evaluating patients undergoing TAVI, 30\u2010day mortality was higher among women than men driven by significant higher rates of major or life\u2010threatening bleeding and major vascular complications. However, all\u2010cause mortality on long\u2010term follow\u2010up was similar between groups. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26658","type":"journal-article","created":{"date-parts":[[2017,2,21]],"date-time":"2017-02-21T16:16:25Z","timestamp":1487693785000},"page":"429-436","source":"Crossref","is-referenced-by-count":23,"title":["Gender\u2010related differences on short\u2010 and long\u2010term outcomes of patients undergoing transcatheter aortic valve implantation"],"prefix":"10.1002","volume":"89","author":[{"given":"Marcelo","family":"Katz","sequence":"first","affiliation":[{"name":"Hospital Israelita Albert Einstein S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Carlos Bacelar Nunes Filho","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein S\u00e3o Paulo SP 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