{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T04:46:48Z","timestamp":1766983608207},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,8,27]],"date-time":"2016-08-27T00:00:00Z","timestamp":1472256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cathet Cardio Intervent"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare indications and clinical outcomes of two contemporary left atrial appendage (LAA) percutaneous closure systems in a \u201creal\u2010world\u201d population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Percutaneous LAA occlusion is an emerging therapeutic option for stroke prevention in atrial fibrillation. Some questions however remain unanswered, such as the applicability of results of randomized trials to current clinical practice. Moreover, currently available devices have never been directly compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed consecutive patients who underwent LAA closure at San Raffaele Hospital, Milan, Italy between 2009 and 2015. Clinical indications and device selection were left to operators' decision; routine clinical and transesophageal echocardiography (TEE) follow\u2010up was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>One\u2010hundred and sixty\u2010five patients were included in the study, of which 99 were treated with the Amplatzer Cardiac Plug (ACP) and 66 with the Watchman system. During the follow\u2010up period (median 15 months, interquartile range 6\u201326 months) five patients died. The incidence of ischemic events was low, with one patient suffering a transient ischemic attack and no episodes recorded of definitive strokes. Twenty\u2010six leaks \u22651 mm were detected (23%); leaks were less common with the ACP and with periprocedural three\u2010dimensional TEE evaluation, but were not found to correlate with clinical events. Clinical outcomes were comparable between the two devices.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our data show excellent safety and efficacy of LAA closure, irrespectively of the device utilized, in a population at high ischemic and hemorrhagic risk. The use of ACP and 3D\u2010TEE minimized the incidence of residual leaks; however, the clinical relevance of small peri\u2010device flow warrants further investigation. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/ccd.26678","type":"journal-article","created":{"date-parts":[[2016,8,27]],"date-time":"2016-08-27T14:49:20Z","timestamp":1472309360000},"page":"763-772","source":"Crossref","is-referenced-by-count":24,"title":["Left atrial appendage closure: A single center experience and comparison of two contemporary devices"],"prefix":"10.1002","volume":"89","author":[{"given":"Filippo","family":"Figini","sequence":"first","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"},{"name":"EMO\u2010GVM Centro Cuore Columbus Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizio","family":"Mazzone","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damiano","family":"Regazzoli","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giulia","family":"Porata","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Ruparelia","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"},{"name":"EMO\u2010GVM Centro Cuore Columbus Milan Italy"},{"name":"Imperial College London United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Giannini","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"},{"name":"EMO\u2010GVM Centro Cuore Columbus Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Stella","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Ancona","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eustachio","family":"Agricola","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicoleta","family":"Sora","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Marzi","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Aurelio","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Trevisi","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paolo","family":"Della Bella","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Colombo","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"},{"name":"EMO\u2010GVM Centro Cuore Columbus Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Montorfano","sequence":"additional","affiliation":[{"name":"Interventional Cardiology Department San Raffaele Hospital Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,27]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"e29","article-title":"American Heart Association Statistics C, Stroke Statistics S. 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